Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage-Randomized, Placebo-Controlled, Double-Blind, Crossover Study-
Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage-Randomized, Placebo-Controlled, Double-Blind, Crossover Study-
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DOI：
10.1248/bpb.b15-00662
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发表时间：
2016-05-01
影响因子：
2
通讯作者：
Fukuhara, Ikuo
中科院分区：
文献类型：
--
作者：
Ashigai, Hiroshi;Taniguchi, Yoshimasa;Fukuhara, Ikuo
肥胖是一种严重的医学疾病，在世界范围内。抑制脂质吸收对预防肥胖非常重要。在以前的研究中，我们发现，餐后升高的三酰甘油抑制摄入的红茶多酚（BTP）。我们还报道了在动物研究中，BTP导致脂质排泄到粪便中。本研究是一项检查脂质排泄的临床试验。在这项随机、安慰剂对照、双盲、交叉研究中，在第一个测试期，参与者被要求饮用含有55 mg BTP的饮料或不含BTP的对照饮料，每天3次，持续10 d。在11天的间隔后，对于第二个测试期，他们每天喝3次替代测试饮料，持续10天。在测试期间，参与者被要求根据卡路里和脂肪含量标准化饮食。在每个试验期的最后3天采集粪便样本，用于粪便脂质测量。与摄入对照饮料相比，摄入BTP后，总脂质排泄量从5.51 +/- 1.73增加到6.87 +/- 1.91 g/3 d。这些结果表明，BTP增加脂质排泄。
Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51 +/- 1.73 to 6.87 +/- 1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.