Intraocular penetration of vancomycin.
Intraocular penetration of vancomycin.
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万古霉素眼内渗透。
DOI：
10.1001/archopht.1962.00960020608015
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发表时间：
1962
影响因子：
--
通讯作者：
I. Leopold
中科院分区：
文献类型：
--
作者：
J. Pryor;L. Apt;I. Leopold
前言万古霉素是一种从东方链霉菌菌株中获得的杀菌抗生素，于1956年在礼来公司研究实验室发现。3对葡萄球菌、溶血性链球菌、肠球菌、肺炎球菌、棒状杆菌和梭状芽孢杆菌有活性。所有临床分离的葡萄球菌对万古霉素的作用都很敏感，它已经用于治疗各种葡萄球菌感染，取得了良好的效果。6，7万古霉素在治疗对青霉素、四环素和红霉素等其他抗生素耐药的葡萄球菌引起的感染时特别有用，一些当局认为它是治疗对常用抗生素耐药的严重葡萄球菌感染的首选药物之一。静脉给药后很容易达到1，2高水平，葡萄球菌通常对每毫升低于5μG的万古霉素敏感。万古霉素目前只能作为一种静脉制剂使用，万古霉素是礼来公司实验室的一种产品。什么时候
Introduction Vancomycin is a bactericidal antibiotic obtained from strains of Streptomyces orientalis and discovered in 1956 at the Eli Lilly Research Laboratories. 3 It is active against staphylococci, hemolytic streptococci, enterococci, pneumococci, corynebacteria, and clostridia. All clinically isolated staphylococci are sensitive to vancomycin's action, and it has been used against a wide variety of staphylococci infections with excellent results. 6,7 Vancomycin is particularly useful in the treatment of infections due to staphylococci which are resistant to other antibiotics such as penicillin, tetracycline, and erythromycin, and it is considered by some authorities to be among the drugs of choice in treating severe staphylococcic infections which are resistant to the commonly used antibiotics. 1,2 High blood levels are readily attained following intravenous administration, and staphylococci are generally sensitive to less than 5μg. of vancomycin per milliliter. Vancomycin is currently available only as an intravenous preparation—Vancocin, intravenous—a product of Eli Lilly Laboratories. When