BODY IRON STORES AND RISK OF CANCER
BODY IRON STORES AND RISK OF CANCER
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DOI：
10.1002/ijc.2910560315
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发表时间：
1994-02-01
影响因子：
6.4
通讯作者：
HAKULINEN, T
中科院分区：
文献类型：
--
作者：
KNEKT, P;REUNANEN, A;HAKULINEN, T
高水平的可利用组织铁可能通过促进氧自由基的产生而增加患癌症的风险。研究了血清铁、总铁结合力(TIBC)和转铁蛋白饱和度水平对不同癌症的预测作用，对年龄在20-74岁、最初未患癌症的41,276名男性和女性进行了研究。在平均14年的随访中，2469例原发癌症被诊断出来。转铁蛋白饱和度水平超过60%的受试者患结直肠癌和肺癌的风险较高。与水平较低的受试者相比，调整了年龄、性别和吸烟因素后，结直肠癌的相对风险为3.04，肺癌的相对风险为1.51。肺癌的风险与血清TIBC呈负相关，男性的相对风险在最高和最低四分位数之间，男性为0.69，女性为0.19。对于胃癌的风险，我们发现与血清铁和转铁蛋白饱和度呈负相关，与TIBC呈正相关，但当排除发生在随访前5年的癌症病例时，这些相关性减弱。高铁储备可能会增加患结直肠癌的风险，而低铁储备可能是隐匿性胃癌的早期迹象。(C)1994年Wiley-Liss，Inc.
A high level of available tissue iron may increase the risk of cancer through its contribution to the production of free oxygen radicals. Serum iron, total iron-binding capacity (TIBC) and transferrin saturation levels were studied for their prediction of different cancers in a cohort of 41,276 men and women aged 20-74 years and initially free from cancer. During a mean follow-up of 14 years, 2,469 primary cancer cases were diagnosed. Excess risks of colorectal and lung cancers were found in subjects with transferrin saturation level exceeding 60%. The relative risks, adjusted for age, sex and smoking, were 3.04 for colorectal cancer and 1.51 for lung cancer, in comparison with subjects having lower levels. The risk of lung cancer was inversely related to serum TIBC, with a relative risk between the highest and lowest quartiles of 0.69 for men and 0.19 for women. For the risk of stomach cancer, we detected inverse relationships with serum iron and with transferrin saturation and a positive relationship with TIBC, but these associations weakened when the cancer cases occurring during the 5 first years of follow-up were excluded. High iron stores may increase the risk of colorectal cancer, whereas low iron stores may be an early sign of occult stomach cancer. (C) 1994 Wiley-Liss, Inc.