Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft
Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft
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DOI：
10.1111/j.1600-0501.2009.01891.x
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发表时间：
2010-05-01
影响因子：
4.3
通讯作者：
Comenalli Marques, Jose Francisco, Jr.
中科院分区：
文献类型：
--
作者：
Pelegrine, Andre Antonio;Sorgi da Costa, Carlos Eduardo;Comenalli Marques, Jose Francisco, Jr.
目的本研究的目的是评估自体骨髓移植在保存牙槽嵴后extraction.MaterialsThirteen患者需要提取30上前牙纳入本研究。他们被随机分为两组：试验组7名患者，15颗牙齿将被拔除，对照组6名患者，15颗牙齿将被拔除。血液科医生在提取前即刻从试验组患者的髂嵴采集5 ml骨髓。拔牙和颊全层皮瓣提升后，钛螺钉定位在整个颊舌板，并作为测量目的的参考点。在试验部位用自体骨髓移植牙槽，在对照部位不移植任何东西。6个月后，重新打开这些部位，测量厚度和高度的骨丢失。此外，种植体植入前，骨芯收获和准备组织学和histomorphometric evaluation.ResultsThe测试组表现出更好的结果（P < 0.05）在保存牙槽嵴厚度，与1.14 +/- 0.87毫米（中位数1）的骨丢失，与对照组相比，有2.46 +/- 0.4毫米（中位数2.5）的骨丢失。对照组颊板上的骨丢失高度也大于试验组（P < 0.05），分别为1.17 ± 0.26 mm（中位数1）和0.62 ± 0.51 mm（中位数0.5）。在对照组的5个位置，需要扩张或植骨辅助手术来安装植入物，而试验组的任何位置都不需要这些手术。组织形态计量学分析显示，对照组和试验组的矿化骨量相似，为42.87 ± 11.33%。（中位数43.75%）和45.47 +/- 7.21%结论自体骨髓移植可促进拔牙后牙槽骨的修复。Pelegrine AA，da Costa CES，Correa MEP，Marques JFC Jr.自体骨髓移植治疗拔牙窝的临床和组织形态学评价。Res. 21，2010; 535-542.doi：10.1111/j.1600-0501.2009.01891.x.
PurposeThe aim of this study was to evaluate the potential of an autologous bone marrow graft in preserving the alveolar ridges following tooth extraction.MaterialsThirteen patients requiring extractions of 30 upper anterior teeth were enrolled in this study. They were randomized into two groups: seven patients with 15 teeth to be extracted in the test group and six patients with 15 teeth to be extracted in the control group. Hematologists collected 5 ml of bone marrow from the iliac crest of the patients in the test group immediately before the extractions. Following tooth extraction and elevation of a buccal full-thickness flap, titanium screws were positioned throughout the buccal to the lingual plate and were used as reference points for measurement purposes. The sockets were grafted with an autologous bone marrow in the test sites and nothing was grafted in the control sites. After 6 months, the sites were re-opened and bone loss measurements for thickness and height were taken. Additionally, before implant placement, bone cores were harvested and prepared for histologic and histomorphometric evaluation.ResultsThe test group showed better results (P < 0.05) in preserving alveolar ridges for thickness, with 1.14 +/- 0.87 mm (median 1) of bone loss, compared with the control group, which had 2.46 +/- 0.4 mm (median 2.5) of bone loss. The height of bone loss on the buccal plate was also greater in the control group than in the test group (P < 0.05), 1.17 +/- 0.26 mm (median 1) and 0.62+0.51 (median 0.5), respectively. In five locations in the control group, expansion or bone grafting complementary procedures were required to install implants while these procedures were not required for any of the locations in the test group. The histomorphometric analysis showed similar amounts of mineralized bone in both the control and the test groups, 42.87 +/- 11.33% (median 43.75%) and 45.47 +/- 7.21% (median 45%), respectively.ConclusionThese findings suggest that the autologous bone marrow graft can contribute to alveolar bone repair after tooth extraction.To cite this article:Pelegrine AA, da Costa CES, Correa MEP, Marques JFC Jr. Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft.Clin. Oral Impl. Res. 21, 2010; 535-542.doi: 10.1111/j.1600-0501.2009.01891.x.