Integrated urate sensors for detecting wound infection
Integrated urate sensors for detecting wound infection
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DOI：
10.1016/j.elecom.2008.02.025
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发表时间：
2008-05
影响因子：
5.4
通讯作者：
D. Sharp;James Davis
中科院分区：
文献类型：
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作者：
D. Sharp;James Davis
评估了使用碳纤维网作为“智能绷带”中的传感元件来评估伤口渗出物中尿酸盐转化的适用性，并提出了一种检测细菌污染的新策略。设计了原型传感器组件，并对其对全血、血清、水泡液和微生物培养中尿酸的定期监测的响应特性进行了评估。铜绿假单胞菌是引起大多数不定创面感染的细菌，它对尿酸的快速和选择性代谢进行了研究。对利用微生物对内源性伤口尿酸盐的反应作为检测感染开始的手段的有效性进行了初步评估。
The applicability of employing a carbon fibre mesh as the sensing element within a “smart bandage” for assessing urate transformations within wound exudates is evaluated and a novel strategy for the detection of bacterial contamination presented. Prototype sensor assemblies have been designed and their response characteristics towards the periodic monitoring of uric acid within whole blood, serum, blister fluid and microbial culture has been evaluated. The rapid and selective metabolism of urate by Pseudomonas aeruginosa, the bacteria responsible for most adventitious wound infections, has been investigated. A preliminary evaluation of the efficacy of utilizing the microbial response to endogenous wound urate as means of detecting the onset of infection is presented.