Dental age estimation in children with chromosomal syndromes
Dental age estimation in children with chromosomal syndromes
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染色体综合征儿童的牙齿年龄估计
DOI：
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发表时间：
2018
影响因子：
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通讯作者：
M. Focardi
中科院分区：
文献类型：
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作者：
V. Pinchi;G. Vitale;F. Pradella;L. Farese;M. Focardi
当一个人的年龄未知时，年龄评估是指当局试图确定一个人实际年龄的程序。牙科证据被证明是非常有效的估计年龄和牙齿矿化在很大程度上被认为是一个过程，几乎不受重大疾病和营养或环境因素，可以影响儿童的成长。本研究旨在了解遗传综合征对受影响个体牙齿成熟的可能影响。样本由159名受染色体影响的儿童（69名男性和90名女性）的测试样本和157名健康儿童（77名男性和80名女性）的对照样本组成，年龄在4.49岁至19.8岁之间。应用伦敦Atlas估计OPG（曲面断层摄影）的牙龄。综合征患者和健康人的牙齿估计值无统计学显著差异。此外，性别和年龄组之间没有统计学显著差异。与未受影响的受试者相比，受唐氏综合征或威廉姆斯综合征影响的儿童的平均误差和每个年龄组的平均准确度均无差异。伦敦图谱可有效地应用于唐氏综合征和威廉姆斯综合征等多发性发育不全个体的年龄估计，即使在综合征和健康样本中系统地发生年龄的轻微高估。目前的研究结果表明，牙齿成熟是一个非常稳定的生物过程，几乎不受遗传综合征等严重疾病的影响。
When the age of an individual is unknown, age assessment refers to the procedures through which authorities try to establish the chronological age of an individual. Dental evidence demonstrated to be very effective in estimating age and dental mineralization is largely deemed a process scarcely influenced by major diseases and nutritional or environmental factors which can affect child growth. This research aims to understand the possible influence of genetic syndromes on dental maturation of affected individuals. The sample is composed of a test sample of 159 chromosomal affected children, 69 males and 90 females, and a control sample of 157 healthy children, 77 males and 80 females aged between 4,49 and 19,8years. London Atlas was applied to estimate dental age on OPGs (orthopantompographies). No statistical significant difference has been found in dental estimates between syndromic and healthy individuals. Moreover no statistical significant difference emerged between sexes and age cohorts. Children affected by Down or Williams syndromes nor mean error neither the mean accuracy per cohort of age show differences compared to non-affected subjects. The London Atlas can be validly applied to age estimation of individuals with multiple agenesis as in Down and Williams syndromes, even if it a slight overestimation of age occurs systematically in syndromic as well as in healthy samples. The current findings suggest that dental maturation is a very stable biological process scarcely affected by even serious illnesses as genetic syndromes.