Evaluation of passive mixing behaviors in a pillar obstruction poly(dimethylsiloxane) microfluidic mixer using fluorescence microscopy
Evaluation of passive mixing behaviors in a pillar obstruction poly(dimethylsiloxane) microfluidic mixer using fluorescence microscopy
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DOI：
10.1007/s10404-008-0386-1
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发表时间：
2009-08-01
影响因子：
2.8
通讯作者：
Song, Joon Myong
中科院分区：
文献类型：
--
作者：
Chen, Lingxin;Wang, Guoqing;Song, Joon Myong
通过微流体通道的流体的快速混合对于微流体系统的各种应用非常重要。在微流体系统中实现高效混合一直是一个巨大的挑战，因为在低雷诺数（Re）下在亚毫米尺寸的通道中产生湍流是非常困难的。在本文中，我们制作了一个柱阻塞微流体混合器，并评估其在不同流量的混合效率。使用荧光显微镜估计汇合流的混合行为。三组不同的可混溶溶液（磷酸盐缓冲溶液，金纳米胶体和20%甘油），与罗丹明6G水溶液，被用作样品层流。根据我们的实验结果，柱阻塞微流控混合器显示出良好的混合性能在低Re范围内。在这里，混合性能强烈依赖于不同的可混溶溶液的特性粘度变化。本文设计的柱阻塞微流控混合器由于制作简单，在低Re下混合效率高，有望在芯片实验室中得到广泛应用。
The rapid mixing of fluids passing through a microfluidic channel is very important for various applications of microfluidic systems. It has been a great challenge to achieve highly efficient mixing in a microfluidic system because it is very difficult to generate turbulence in a submillimeter-size channel at low Reynolds numbers (Re). In this paper, we fabricated a pillar obstruction microfluidic mixer and evaluated its mixing efficiency at various flow rates. The mixing behavior of confluent streams was estimated using a fluorescence microscope. Three different sets of miscible solutions (phosphate-buffered solution, gold nanocolloids and 20% glycerol), with Rhodamine 6G aqueous solution, were used as sample laminar flows. According to our experimental results, the pillar obstruction microfluidic mixer shows an excellent mixing performance in the low Re range. Here, the mixing performance was strongly dependent on the characteristic viscosity changes of different sets of miscible solutions. The pillar obstruction microfluidic mixer designed here is expected to benefit a wide range of lab-on-a-chip applications because fabrication is very simple and the mixing efficiency is excellent at low Re.