From structural modalities in perinatal medicine to the frequency of preterm birth.
From structural modalities in perinatal medicine to the frequency of preterm birth.
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DOI：
10.1007/s00281-020-00805-0
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发表时间：
2020-08
影响因子：
9
通讯作者：
Diemert A
中科院分区：
文献类型：
--
作者：
Deindl P;Diemert A
早产是一个全球性的健康问题，影响到所有活产婴儿的11%：它仍然是死亡的重要原因，也是世界各地幸存者长期丧失人类潜力的重要原因。在过去十年中，许多发达国家的早产儿比率有所上升。各种理论和实践的概念进行了讨论，旨在优化早产儿及其母亲的围产期护理。这些措施包括对不同护理水平的医院的定义、护理区域化、建立病例数高的大型护理单位和高水平的专业知识。这篇综述文章的重点是医疗保健结构和早产的不同方面之间的联系。此外，这篇综述文章强调了早产是一种异质性综合征，具有许多基础病理学，大量病例的因果关系仍然无法解释。关于自发性早产的实际驱动因素仍然存在重大的知识差距，未来的研究，特别是分娩免疫学和早产遗传学的研究对于确定新的治疗靶点至关重要。
Preterm birth is a global health problem that affects 11% of all live births: it remains a significant cause of death and an important cause of long-term loss of human potential among survivors all around the world. In the last decade, many developed countries have seen an increase in the rate of infants born preterm. Various theoretical and practical concepts have been discussed that aim to optimize the perinatal care of preterm infants and their mothers. These include the definition of hospitals with different levels of care, the regionalization of care, the creation of large care units with high case numbers, and a high level of expertise. This review article focuses on the connection between health care structures and different aspects of preterm birth. Furthermore, this review article highlights the fact that preterm birth is a heterogeneous syndrome with many underlying pathologies and that the causality for a large number of cases remains unexplained. There is still a significant knowledge gap concerning the actual drivers of spontaneous preterm birth, and future research particularly in parturition immunology as well as genetics of prematurity will be essential to identify new targets for therapy.
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影响因子：
168.9
作者：
Lawn, Joy E.;Blencowe, Hannah;Stanton, Cynthia
通讯作者：
Stanton, Cynthia
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影响因子：
2.1
作者：
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通讯作者：
Barfield WD
影响因子：
158.5
作者：
Hillier, SL;Nugent, RP;Klebanoff, MA
通讯作者：
Klebanoff, MA
影响因子：
8
作者：
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通讯作者：
Spitzer, Alan R.
影响因子：
2.4
作者：
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通讯作者：
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