Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water
Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water
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DOI：
10.1038/s41467-019-12586-8
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发表时间：
2019-10-17
影响因子：
16.6
通讯作者：
Perrier, Sebastien
中科院分区：
文献类型：
--
作者：
Rho, Julia Y.;Cox, Henry;Perrier, Sebastien
自组装肽具有自发聚集成大的有序结构的能力。肽氢键超分子组装的可逆性使它们可调节到许多不同的应用，尽管它使它们高度动态并且易于在生物应用所需的低浓度下分解。在这里，我们证明了二级疏水相互作用，附近的肽核心，可以稳定的高度动态的肽键，而不会失去重要的溶解度的系统在水性条件下。这种分层自组装过程可用于稳定一系列不同的β-折叠氢键结构。
Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different beta-sheet hydrogen bonded architectures.