CYTOKINES IN INTESTINAL INFLAMMATION - PATHOPHYSIOLOGICAL AND CLINICAL CONSIDERATIONS
CYTOKINES IN INTESTINAL INFLAMMATION - PATHOPHYSIOLOGICAL AND CLINICAL CONSIDERATIONS
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DOI：
10.1016/0016-5085(94)90614-9
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发表时间：
1994-02-01
期刊：
影响因子：
29.4
通讯作者：
SARTOR, RB
中科院分区：
文献类型：
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作者：
SARTOR, RB
无论特定的启动事件如何，肠炎状态都有共同的免疫介导的组织损伤和修复途径。免疫、间充质和上皮细胞的激活、循环效应细胞的募集、组织损伤和愈合是由激活的肠道细胞释放的可溶性生化介质的复杂平衡的结果。这些介质包括细胞因子、花生四烯酸代谢产物、活性氧中间体和生长因子，它们与肠道炎症有关，具有重要的调节和效应活性。细胞因子是由激活的免疫细胞产生的蛋白质，影响其他细胞的活性、分化或增殖。这些蛋白在炎症性肠病(IBD)的发病机制中起着关键作用，但在其他肠道炎症条件下还没有任何详细的研究。然而，细胞因子几乎肯定会在感染性小肠结肠炎、乳糜泻、显微镜下粘连性结肠炎、移植物对宿主疾病、嗜酸性胃肠炎和缺血或辐射诱导的小肠结肠炎中介导组织损伤。这篇综述将简要讨论细胞因子的病理生理学后果，它们在肠道炎症中的测量，以及这些分子作为疾病活动的标志和新的治疗干预的靶点的临床相关性。
I ntestinal inflammatory states, regardless of specific initiating events, share common immunologically mediated pathways of tissue injury and repair. Activation of immune, mesenchymal, and epithelial cells; recruitment of circulating effector cells; tissue damage; and healing are the consequence of a complex balance of soluble biochemical mediators released by activated intestinal cells. These mediators include cytokines, arachidonic acid metabolites, reactive oxygen intermediates, and growth factors that have important regulatory and effector activities relevant to intestinal inflammation. Cytokines are proteins produced by activated immune cells that influence the activity, differentiation, or proliferation of other cells. These proteins play a key role in the pathogenesis of infammatory bowel disease (IBD), but have not yet been investigated in any detail in other intestinal inflammatory conditions.’However, cytokines almost certainly mediate tissue injury in infectious enterocolitis, celiac disease, microscopicicollagenous colitis, graft vs. host disease, eosinophilic gastroenteritis, and ischemicor radiation-induced enterocolitis. This review will briefly discuss the pathophysiological consequences of cytokines, their measurements in intestinal inflammation, and the clinical relevance of these molecules as markers of disease activity and targets for novel therapeutic intervention.