ALZHEIMER-DISEASE - EVIDENCE FOR SELECTIVE LOSS OF CHOLINERGIC NEURONS IN THE NUCLEUS BASALIS
ALZHEIMER-DISEASE - EVIDENCE FOR SELECTIVE LOSS OF CHOLINERGIC NEURONS IN THE NUCLEUS BASALIS
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DOI：
10.1002/ana.410100203
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发表时间：
1981-01-01
影响因子：
11.2
通讯作者：
DELONG, MR
中科院分区：
文献类型：
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作者：
WHITEHOUSE, PJ;PRICE, DL;DELONG, MR
Meynert基底核向新皮质提供弥散性胆碱能输入。当与年龄和性别匹配的对照组相比时，阿尔茨海默病患者的基底核显示出神经元的大量减少。这种神经元群体的丧失可能代表了阿尔茨海默病中胆碱能紊乱的解剖学相关性。
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.