Bicuculline enhances a negative component and diminishes a positive component of the visual evoked cortical potential in the cat.
Bicuculline enhances a negative component and diminishes a positive component of the visual evoked cortical potential in the cat.
复制标题
荷包牡丹碱增强猫视觉诱发皮层电位的负成分并减少正成分。
DOI：
10.1073/pnas.77.12.7476
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发表时间：
1980
影响因子：
11.1
通讯作者：
Ratliff,F
中科院分区：
文献类型：
--
作者：
Zemon,V;Kaplan,E;Ratliff,F
在猫的头皮和视皮层表面记录了局部应用荷包牡丹碱前后的视觉诱发电位（VEP）。这种药物的应用大大改变了VEP：正常小的负成分的幅度大大增加，而正常突出的晚期阳性成分减少。已知荷包牡丹碱可阻断γ-氨基丁酸的作用，而γ-氨基丁酸被认为是视觉皮层中的主要抑制性神经递质。因此，我们认为，受影响的负波反映了视觉皮层的兴奋过程，受影响的晚期正波反映了皮层内的抑制过程。
Visual evoked potentials (VEPs), elicited by modulation of luminance of homogeneous fields of light, were recorded from the scalp and from the surface of the visual cortex of cats before and after topical application of bicuculline to the cortex. The application of this drug drastically altered the VEP: the amplitude of a normally small negative component was increased greatly, and a normally prominent late positive component was diminished. Bicuculline is known to block the action of gamma-aminobutyric acid, which is thought to be the primary inhibitory neurotransmitter in the visual cortex. We suggest, therefore, that the affected negative wave reflects an excitatory process in the visual cortex and that the affected late positive wave reflects an intracortical inhibitory process.