Neuropsychological aspects of epilepsy surgery
Neuropsychological aspects of epilepsy surgery
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DOI：
10.1016/j.yebeh.2003.11.006
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发表时间：
2004-02-01
影响因子：
2.6
通讯作者：
Helmstaedter, C
中科院分区：
文献类型：
--
作者：
Helmstaedter, C
癫痫手术前后对患者认知能力的神经心理学评估在择期癫痫手术中至关重要。一方面，神经心理学提供了关于癫痫相关认知障碍的定位和偏侧化的辅助信息;另一方面，它是癫痫手术质量和结果控制的有用工具，有助于使手术更加有效和安全。对要切除的脑组织的充分性和患者的精神储备能力的评估允许对术后认知发展进行预测。成功的手术可以阻止由于慢性癫痫导致的智力下降，并且可以通过释放手术前继发性影响的功能和能力来扭转这种负面趋势。然而，手术承担额外损害的风险，这些损害与正常或甚至病理性的心理衰老过程相互作用，可能会加速老年人的认知能力下降。从神经心理学的角度来看，早期识别药物抗性是重要的，沿着早期和完全控制癫痫发作，最大限度地保留功能组织。(C)2003年爱思唯尔公司All rights reserved.
Neuropsychological evaluation of a patient's cognitive capabilities before and after epilepsy surgery is essential in elective epilepsy surgery. On the one hand, neuropsychology provides accessory information regarding the localization and lateralization of epilepsy-associated cognitive impairment; on the other hand, it is a useful tool for quality and outcome control of epilepsy surgery which helps to make surgery more effective and safe. Evaluation of the adequacy of the brain tissues to be resected and of the patient's mental reserve capacities allows for a prediction of the postoperative cognitive development. Successful surgery can stop mental decline due to chronic epilepsy and it can reverse this negative trend by release of functions and capacities that were secondarily affected before surgery. However, surgery bears the risk of additional impairments which, in interaction with normal or even pathological processes of mental aging, may accelerate cognitive decline at an older age. From a neuropsychological point of view, early recognition of pharmacoresistance is important along with early and complete seizure control with maximal sparing of functional tissues. (C) 2003 Elsevier Inc. All rights reserved.