Hepatitis C virus RNA present in saliva but absent in breast‐milk of the hepatitis C carrier mother
Hepatitis C virus RNA present in saliva but absent in breast‐milk of the hepatitis C carrier mother
复制标题
丙型肝炎病毒携带者母亲的唾液中存在丙型肝炎病毒 RNA，但母乳中不存在丙型肝炎病毒 RNA
DOI：
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发表时间：
1997
影响因子：
4.1
通讯作者：
M. Sata
中科院分区：
文献类型：
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作者：
M. Kage;S. Ogasawara;K. Kosai;E. Nakashima;K. Shimamatsu;M. Kojiro;A. Kimura;T. Fujisawa;Yoshinori Matsukuma;Yuji Ito;Shigenobu Kondo;K. Kawano;M. Sata
为了检查唾液和母乳是否是丙型肝炎病毒携带者母亲垂直传播丙型肝炎病毒的媒介，11名丙型肝炎病毒携带者母亲在分娩时收集了血清、唾液和母乳样本，大约每隔1-3个月收集一次，长达产后30个月。还从他们的孩子身上采集了血清。用套式聚合酶链式反应方法分析所有样本中是否存在丙型肝炎病毒RNA。在任何母乳样本中均未检测到丙型肝炎病毒核糖核酸。在唾液中，在11名母亲中有4名(36%)检测到了丙型肝炎病毒RNA。这四位母亲也有肝功能异常。所有患儿血清标本中均未检出丙型肝炎病毒RNA，所有患儿肝功能正常。这些儿童接受了从2个月到44个月的监测。在此期间，没有病毒传播的证据。母乳不太可能是丙型肝炎病毒母婴传播的来源。母亲的唾液可能携带丙型肝炎病毒，但不会导致婴儿感染。
In order to examine whether saliva and breast‐milk are mediators of the vertical transmission of hepatitis C virus (HCV) from an HCV carrier mother, serum, saliva, and breast‐milk samples from 11 HCV carrier mothers were collected at the time of delivery, and at approximately 1‐ to 3‐month intervals for as long as 30 months postpartum. Serum was also sampled from their children. All samples were analysed for the presence of HCV RNA, using the nested polymerase chain reaction method. No HCV RNA was detected in any breast‐milk samples. In saliva, HCV RNA was detected in four of the 11 mothers (36%). These four mothers also had liver function abnormalities. Hepatitis C virus RNA was not detected in any serum samples of the children, and all children had normal liver function. The children were monitored for periods from 2 to 44 months. During this period, there was no evidence of virus transmission. Breast‐milk is not likely to be a source of mother‐to‐child transmission of HCV. Maternal saliva may harbour HCV, but it may not result in infant infection.
DOI：
10.1056/nejm199408113310612
发表时间：
1994-08
期刊：
The New England journal of medicine
影响因子：
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作者：
B. Gürakan;O. Oran;S. Yiğit
通讯作者：
B. Gürakan;O. Oran;S. Yiğit