High birth weight and obesity-a vicious circle across generations
High birth weight and obesity-a vicious circle across generations
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DOI：
10.1038/ijo.2011.248
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发表时间：
2012-10-01
影响因子：
4.9
通讯作者：
Granath, F.
中科院分区：
文献类型：
--
作者：
Cnattingius, S.;Villamor, E.;Granath, F.
目的：高出生体重儿、超重和肥胖儿童和成人的比例呈上升趋势。出生体重和成人体重之间的关联可能会导致肥胖症在几代人之间流行。我们研究了母亲的出生体重与胎龄和成人体重指数(BMI)之间的关系，以及这些因素对胎龄较大(>；+2S.D.)后代的风险的联合影响。设计：一组162 676名母亲及其头胎子女的出生信息记录在1973年至2006年瑞典医学出生登记簿上。结果：与出生体重与胎龄相适应的母亲(AGA；-1比+1 S.D.)相比，出生LGA的母亲超重的风险增加(BMI 25.0-29.9；优势比(OR)1.50；95%CI 1.39-1.61)，I类肥胖(BMI 30.0-34.9；OR 1.77；肥胖II级(BMI 35.0~39.9；OR 2.77；95%CI 2.37~3.24)；肥胖III级(BMI>；=40.0；OR 2.04；95%CI 1.49~2.80)。在母亲出生体重与胎龄的每一层中，生下低出生体重的风险随着母亲的BMI而增加。体重指数高(>；=30)且胎龄出生体重高(>；+1S.D.)的女性，其LGA后代的风险最高。在这些组中，与出生时体重指数正常的AGA母亲相比，LGA后代的OR值为5~14(与BMI正常的SGA母亲相比，OR值分别为35.0和0.35)。结论：产前状况是肥胖流行的重要因素。预防LGA出生可能有助于减少肥胖的代际恶性循环。
OBJECTIVES: Rates of high birth weight infants, overweight and obese children and adults are increasing. The associations between birth weight and adult weight may have consequences for the obesity epidemic across generations. We examined the association between mothers' birth weight for gestational age and adult body mass index (BMI) and these factors' joint effect on risk of having a large-for-gestational-age (LGA) offspring (>+2 s.d. above the mean).DESIGN: A cohort of 162 676 mothers and their first-born offspring with birth information recorded on mothers and offspring in the nation-wide Swedish Medical Birth Register 1973-2006.RESULTS: Compared with mothers with appropriate birth weight for gestational age (AGA; -1 to +1 s.d.), mothers born LGA had increased risks of overweight (BMI 25.0-29.9; odds ratio (OR), 1.50; 95% CI 1.39-1.61), obesity class I (BMI 30.0-34.9; OR 1.77; 95% CI 1.59-1.98), obesity class II (BMI 35.0-39.9; OR 2.77; 95% CI 2.37-3.24) and obesity class III (BMI >= 40.0; OR 2.04; 95% CI 1.49-2.80). In each stratum of mother's birth weight for gestational age, risk of having an LGA offspring increased with mother's BMI. The risk of an LGA offspring was highest among women with a high (>= 30) BMI who also had a high birth weight for gestational age (>+1 s.d.). In these groups, the ORs for LGA offspring ranged from 5 to 14 when compared with mothers born AGA with normal BMI (= 35.0 compared with the OR among SGA mothers with normal BMI (ORs = 4.61 and 0.35, respectively).CONCLUSIONS: Prenatal conditions are important for the obesity epidemic. Prevention of LGA births may contribute to curtail the intergenerational vicious cycle of obesity.