Epigenetic regulation of epidermal differentiation.
Epigenetic regulation of epidermal differentiation.
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DOI：
10.1101/cshperspect.a015263
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发表时间：
2014-02
影响因子：
5.4
通讯作者：
Carolina N. Perdigoto;V. Valdes;E. Bardot;E. Ezhkova
中科院分区：
文献类型：
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作者：
Carolina N. Perdigoto;V. Valdes;E. Bardot;E. Ezhkova
在细胞中，染色质状态受到高度调控的表观遗传机制的相互作用控制，这些机制包括DNA甲基化和不同组蛋白变体的结合，组蛋白的翻译后修饰和atp依赖性染色质重塑。这些变化改变了染色质的结构，以促进或限制转录机制对DNA的访问。这些表观遗传修饰精巧地协调不同基因的表达，共同构成细胞的表观基因组。在皮肤中，不同的表观遗传调控因子形成一个调控网络，保证皮肤干细胞的维持，同时控制多种皮肤结构的分化。在这篇综述中，我们将讨论皮肤控制的表观遗传机制及其与皮肤病理的关系的最新发现。
In a cell, the chromatin state is controlled by the highly regulated interplay of epigenetic mechanisms ranging from DNA methylation and incorporation of different histone variants to posttranslational modification of histones and ATP-dependent chromatin remodeling. These changes alter the structure of the chromatin to either facilitate or restrict the access of transcription machinery to DNA. These epigenetic modifications function to exquisitely orchestrate the expression of different genes, and together constitute the epigenome of a cell. In the skin, different epigenetic regulators form a regulatory network that operates to guarantee skin stem cell maintenance while controlling differentiation to multiple skin structures. In this review, we will discuss recent findings on epigenetic mechanisms of skin control and their relationship to skin pathologies.