Physiology of chronic spinal pain syndromes - From animal models to biomechanics
Physiology of chronic spinal pain syndromes - From animal models to biomechanics
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DOI：
10.1097/00007632-200211150-00026
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发表时间：
2002-11-15
期刊：
影响因子：
3
通讯作者：
Winkelstein, BA
中科院分区：
文献类型：
--
作者：
DeLeo, JA;Winkelstein, BA
研究设计.本文就脊髓疼痛机制的相关文献和研究现状以及与本研究相关的动物模型进行综述。提供一个实用的讨论脊柱疼痛，既回顾了相关的研究，并连贯地综合了现有的文献机构有关疼痛，伤害性感受，动物建模，损伤生物力学。背景资料摘要。大量详细的文献表明，脊柱疼痛机制相当复杂，涉及许多不同的过程（例如，遗传学、性别、神经生理学和生物力学），其可能有助于临床表现和诊断。这两个文献综述和介绍当前和正在进行的实验室研究。作者的实验室使用啮齿类动物模型的腰椎神经根病的具体结果，阐明了局部神经根生物力学的作用，在启动和维持行为症状的伤害性感受和疼痛。为了理解慢性疼痛，需要结合跨学科方法（如体内生物力学技术）的双向平移方法。提出了一个慢性脊柱疼痛的概念模型，详细说明了损伤、生物力学和伤害性生理学的动态和综合作用。继续研究的领域突出显示，可能有助于指导painingul脊柱关节炎和综合征的管理。
Study Design. The literature and current research related to spinal pain mechanisms were reviewed, as well as animal models related to this study.Objectives. To provide a pragmetic discussion of spinal pain that both reviews relevant research and coherently synthesizes the existing body of literature related to pain, nociception, animal modeling, injury biomenchanics.Summary of Background Data. A detailed body of literature suggests that spinal pain mechanisms are quite complicated and involve a host of different processes (e.g., genetics, gender, neurophysiology, and biomechanics) that may contribute to clinical menifestations and symptoms.Methods. Both a review of the literature and a presentation of current and ongoing laboratory research are presented. Specific findings from the authors' laboratory using a rodent model of lumbar radiculopathy are presented to elucidate the role of local nerve root biomechanics in initiating and maintaining behavioral symptoms of nociception and pain.Results. For an understanding of chronic pain, and bidirectional-translational approach that incorporates cross-disciplinary methods such as in vivo biomechanical techniques is required. A conceptual model of chronic spine pain is proposed that details the dynamic and integrated roles of injury, biomechanics, and nociceptive physiology.Conclusions. Areas of continued research are highlighted that may help to guide the management of paingul spine symtoms and syndromes.