Inflammation-modulating cytokine profile and lipid interaction in HIV-related risk factors for cardiovascular diseases.
Inflammation-modulating cytokine profile and lipid interaction in HIV-related risk factors for cardiovascular diseases.
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DOI：
10.2147/tcrm.s117980
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发表时间：
2016
影响因子：
2.8
通讯作者：
Gomo ZA
中科院分区：
文献类型：
--
作者：
Gori E;Mduluza T;Nyagura M;Stray-Pedersen B;Gomo ZA
HIV 感染和抗逆转录病毒治疗 (ART) 与血浆脂蛋白水平的变化有关，从而增加感染者发生心血管并发症的风险。血浆脂蛋白水平的改变是由控制脂质代谢的炎症调节细胞因子失调引起的。人们对细胞因子和血清脂质水平之间的关系知之甚少，据报道，接受抗逆转录病毒疗法的成人中，细胞因子和血清脂质水平发生了改变。本研究的目的是描述炎症调节细胞因子的概况及其与作为 HIV 感染中心血管疾病 (CVD) 危险因素的脂质的关系。这项观察性横断面研究测量了 HIV 感染者和未感染者的血浆白细胞介素 (IL)-10、肿瘤坏死因子-α (TNF)-α、IL-4、总胆固醇 (TC) 和高密度脂蛋白胆固醇 (HDL-c) 水平。艾滋病毒治疗中心总共招募了 219 名艾滋病毒感染者；其中，187 人正在接受抗逆转录病毒治疗，32 人未接受过抗逆转录病毒治疗，65 人是未感染艾滋病毒的献血者。 HIV 感染者的 IL-10 水平（HIV 感染者未接受 ART 治疗 [P=0.0024] 和接受 ART 治疗 [P=0.033]）高于未感染者。未接受 ART 的受试者血浆 IL-10 水平显着高于接受 ART 的受试者 (P=0.0014)。三组之间血浆 IL-4 和 TNF-α 水平没有观察到显着差异。关于血浆脂蛋白，与未感染 HIV 的受试者相比，未接受过 HIV ART 的受试者 (P=0.002) 和接受 ART 的受试者 (P=0.015) 的 HDL-c 水平降低。同样，无论患者是否接受 ART，HIV 感染者的 TC 水平均低于 HIV 未感染者（P<0.001）。在未感染 HIV 的组中，IL-10 水平与 TC 水平相关，但在 HIV 感染组中则不然。 HIV 感染者的 HDL-c 水平降低，而 IL-10 血浆浓度升高。在未感染 HIV 的个体中观察到的抗炎细胞因子 IL-10 和 TC 之间的相关性在 HIV 感染的个体中消失了。需要确定这些差异对于 HIV 相关 CVD 风险的临床意义。
HIV infection and antiretroviral therapy (ART) are associated with changes in plasma levels of lipoproteins, thus posing the risk of cardiovascular complications in infected individuals. The alteration in plasma lipoprotein levels results from dysregulation of inflammation-modulating cytokines that control lipid metabolism. Little is understood regarding the relationship between the cytokines and serum lipid levels, which have been reported to be altered in adults receiving ART. The objective of this study was to describe the profiles of inflammation-modulating cytokines and their relationship to lipids as cardiovascular disease (CVD) risk factors in HIV infection. This observational cross-sectional study measured plasma levels of interleukin (IL)-10, tumor necrosis factor-alpha (TNF)-α, IL-4, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-c) in HIV-infected and uninfected adults. A total of 219 HIV-infected participants were enrolled from an HIV treatment center; of them, 187 were receiving ART and 32 were ART naïve, while 65 were HIV-uninfected blood donors. HIV-infected individuals had higher levels of IL-10 (HIV-infected ART-naïve [P=0.0024] and ART-receiving [P=0.033]) than their uninfected counterparts. ART-naïve subjects had significantly higher plasma levels of IL-10 than ART-receiving subjects (P=0.0014). No significant difference was observed in plasma levels of IL-4 and TNF-α across the three groups. Regarding plasma lipoproteins, HDL-c levels were reduced in HIV ART-naïve (P=0.002) and ART-receiving (P=0.015) subjects compared to HIV-uninfected subjects. Similarly, TC levels were lower in the HIV-infected than in the HIV-uninfected group regardless of whether the patients were undergoing ART or not (P<0.001). IL-10 levels correlated with TC levels in the HIV-uninfected group but not in the HIV-infected groups. Levels of HDL-c were reduced, while IL-10 plasma concentrations were elevated in HIV-infected individuals. A correlation observed in HIV-uninfected individuals between anti-inflammatory cytokine IL-10 and TC was lost in HIV-infected individuals. Clinical significance of these differences needs to be ascertained with respect to HIV-related CVD risk.