Spinal anterior horn has the capacity to self‐regenerate in amyotrophic lateral sclerosis model mice
Spinal anterior horn has the capacity to self‐regenerate in amyotrophic lateral sclerosis model mice
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DOI：
10.1002/jnr.22156
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发表时间：
2009-12
影响因子：
4.2
通讯作者：
K. Miyazaki;M. Nagai;N. Morimoto;T. Kurata;Y. Takehisa;Y. Ikeda;K. Abe
中科院分区：
文献类型：
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作者：
K. Miyazaki;M. Nagai;N. Morimoto;T. Kurata;Y. Takehisa;Y. Ikeda;K. Abe
肌萎缩侧索硬化症（ALS）神经再生所需的确切宿主环境尚未完全阐明。我们首先关注ALS模型小鼠在疾病发展过程中的细胞外基质蛋白，然后试图检查ALS脊髓在再生条件下是否发生再生。γ1层粘连蛋白（再生的促进剂）进行性增加和semaphorin 3A（Sema 3A;再生的抑制剂）进行性减少，主要是在脊髓前角的神经胶质细胞从15至18周，当星形胶质细胞开始表达γ1层粘连蛋白和Sema 3A。另一方面，从15到18周，在脊髓前角的相同区域观察到生长相关蛋白43（GAP 43;突触再生位点）的进行性增加和突触结合蛋白1（实际突触结）的进行性减少。因此，目前的数据表明，尽管ALS模型中的脊髓前角失去了运动神经元，但它最初具有自我再生的能力，但表现出再生新的有效突触的能力逐渐丧失。© 2009 Wiley利斯公司
The exact host environment necessary for neural regeneration in amyotrophic lateral sclerosis (ALS) has not yet been fully elucidated. We first focused on the extracellular matrix proteins in ALS model mice during development of the disease and then attempted to examine whether regeneration occurs in the ALS spinal cord under regenerative conditions. A progressive increase in γ1 laminin (a promoter of regeneration) and a progressive decrease in semaphorin3A (Sema3A; an inhibitor of regeneration) were observed, mainly in the neuropil of the spinal anterior horn from 15 to 18 weeks, when astrocytes began to express both γ1 laminin and Sema3A. On the other hand, a progressive increase in growth‐associated protein 43 (GAP43; synaptic regeneration site) and a progressive decrease in synaptotagmin1 (actual synaptic bouton) were observed in the same areas of the spinal anterior horn from 15 to 18 weeks. Thus, the present data suggest that, although the spinal anterior horn in ALS models loses motor neurons, it initially possesses the capacity to self‐regenerate but displays a progressive loss of ability to regenerate new effective synapses. © 2009 Wiley‐Liss, Inc.