Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma.
Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma.
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立体定向放射外科治疗骨肉瘤肺转移的潜在替代疗法
DOI：
10.3892/ijo.2014.2295
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发表时间：
2014-04
影响因子：
5.2
通讯作者：
Shen Z
中科院分区：
文献类型：
--
作者：
Yu W;Tang L;Lin F;Li D;Wang J;Yang Y;Shen Z
Stereotactic radiosurgery (SRS), such as body gamma knife, was reported to achieve excellent rates of local disease control with limited toxicity in many cases of primary or secondary pulmonary tumor, except osteosarcoma. To confirm the value of SRS in pulmonary metastases from osteosarcoma, we reviewed the experience from our institution (Department of Oncology, Affiliated Sixth People’s Hospital, Shanghai) and compared the efficiency of SRS with that of surgical resection. From January 2005 to December 2012, we carried out a retrospective investigation of 58 patients (age, 8–59 years; mean, 25.2 years) who were diagnosed with non-metastatic osteosarcoma of the extremity and later developed pulmonary metastasis during the period of adjuvant chemotherapy or follow-up. Among them, 27 patients were treated by SRS using the body gamma-knife system. A total dose of 50 Gy was delivered at 5 Gy/fraction to the 50% isodose line covering the planning target volume, whereas a total dose of 70 Gy was delivered at 7 Gy/fraction to the gross target volume. The other 31 patients were treated by surgical resection. Two-year progression-free survival rate, two-year survival rate, median time of PRPFS (post-relapse progress-free survival) and PROS (post-relapse overall survival) in SRS group were parallel to that in surgical group. All 27 patients tolerated gamma knife radiosurgery well while only 9 patients had grades 1–2 pneumonitis. We believe SRS, compared with surgical resection, is effective and safe in treating pulmonary metastasis from osteosarcoma, especially for those patients who were medically unfit for a resection or who refused surgery.
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影响因子：
8.4
作者：
Bacci, G;Ferrari, S;Smith, KVJ
通讯作者：
Smith, KVJ
DOI：
10.1053/j.semtcvs.2008.12.001
发表时间：
2008-12-01
影响因子：
2.5
作者：
Christie, Neil A.;Pennathur, Arjun;Luketich, James D.
通讯作者：
Luketich, James D.
影响因子：
45.3
作者：
Ozaki, T;Flege, S;Bielack, SS
通讯作者：
Bielack, SS
影响因子：
6.2
作者：
Briccoli, A;Rocca, M;Mercuri, M
通讯作者：
Mercuri, M
影响因子：
45.3
作者：
Bielack, Stefan S.;Kempf-Bielack, Beate;Juergens, Heribert
通讯作者：
Juergens, Heribert