Endo- and Exocytic Budding Transformation of Slow-Diffusing Membrane Domains Induced by Alzheimer’s Amyloid Beta
Endo- and Exocytic Budding Transformation of Slow-Diffusing Membrane Domains Induced by Alzheimer’s Amyloid Beta
复制标题
阿尔茨海默病β淀粉样蛋白诱导的慢扩散膜域的内胞和胞吐出芽转化
DOI：
10.1039/c4cp00434e
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
M. Takagi
中科院分区：
文献类型：
--
作者：
M.Morita;T.Hamada;M. C. Vestergaard;M. Takagi
细胞大小的脂质体是一个强大的工具，阐明物理化学机制，管理分子相互作用。本文中，淀粉样蛋白β肽诱导膜结构域的出芽转化。如膜结构域的布朗运动所示，肽增加了膜粘度。这些结果有助于理解阿尔茨海默病的物理化学机制。
Cell-sized liposomes are a powerful tool for clarifying physicochemical mechanisms that govern molecular interactions. Herein, budding transformation of membrane domains was induced by amyloid beta peptides. The peptides increased the membrane viscosity as demonstrated by the Brownian motion of membrane domains. These results could aid in understanding the physicochemical mechanism of Alzheimer's disease.