TTD: Therapeutic Target Database
TTD: Therapeutic Target Database
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DOI：
10.1093/nar/30.1.412
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发表时间：
2002-01-01
影响因子：
14.9
通讯作者：
Chen, YZ
中科院分区：
文献类型：
--
作者：
Chen, X;Ji, ZL;Chen, YZ
许多蛋白质和核酸已被探索作为治疗靶点。这些目标是生物医学和制药研究的不同领域以及生物信息学、分子建模、计算机辅助药物设计和分析工具的开发和评估中感兴趣的主题。因此，提供有关这些目标的全面信息的可公开查阅的数据库对有关社区是有帮助的。治疗靶点数据库（TTD）旨在提供文献中描述的已知治疗蛋白质和核酸靶点、靶向疾病状况、途径信息和针对这些靶点的相应药物/配体的信息。还引入了与其他数据库的交叉链接，以便于访问有关每个靶点的序列、3D结构、功能、命名、药物/配体结合特性、药物使用和作用以及相关文献的信息。该数据库可在http://xin.cz3.nus.edu.sg/group/ttd/ttd.asp上访问，目前包含涵盖125种疾病状况的433个靶标的条目沿着针对这些靶标中的每一个的809种药物/配体。每个条目可以通过多种方法检索，包括靶标名称、疾病名称、药物/配体名称、药物/配体功能和药物治疗分类。
A number of proteins and nucleic acids have been explored as therapeutic targets. These targets are subjects of interest in different areas of biomedical and pharmaceutical research and in the development and evaluation of bioinformatics, molecular modeling, computer-aided drug design and analytical tools. A publicly accessible database that provides comprehensive information about these targets is therefore helpful to the relevant communities. The Therapeutic Target Database (TTD) is designed to provide information about the known therapeutic protein and nucleic acid targets described in the literature, the targeted disease conditions, the pathway information and the corresponding drugs/ligands directed at each of these targets. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3D structure, function, nomenclature, drug/ligand binding properties, drug usage and effects, and related literature for each target. This database can be accessed at http://xin.cz3.nus.edu.sg/group/ttd/ttd.asp and it currently contains entries for 433 targets covering 125 disease conditions along with 809 drugs/ligands directed at each of these targets. Each entry can be retrieved through multiple methods including target name, disease name, drug/ligand name, drug/ligand function and drug therapeutic classification.