SERIAL CHANGES IN 24-HOUR CREATININE CLEARANCE DURING NORMAL MENSTRUAL CYCLES AND THE FIRST TRIMESTER OF PREGNANCY
SERIAL CHANGES IN 24-HOUR CREATININE CLEARANCE DURING NORMAL MENSTRUAL CYCLES AND THE FIRST TRIMESTER OF PREGNANCY
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DOI：
10.1111/j.1471-0528.1981.tb00930.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
NOBLE, MCB
中科院分区：
文献类型：
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作者：
DAVISON, JM;NOBLE, MCB
连续变化的24小时肌酐清除率测定在11名妇女在几个月经周期前的概念，概念周期和怀孕的第一个三个月。在月经周期中，在月经周和黄体晚期之间平均增加20%。受孕后，这种增加持续，到妊娠第9周平均增加45%。在2例自然流产的妇女中，妊娠早期24小时肌酐清除率的变化既不明显也不持久;这一特征在任何临床异常前至少3周明显。可能的原因，在肾小球滤过率的变化在早孕及其临床意义进行了讨论。
Serial changes in 24 h creatinine clearance were determined in 11 women during several menstrual cycles before conception, the conceptional cycle and the 1st trimester of pregnancy. During the menstrual cycle, a 20% mean increase occurred between the week of menstruation and the late luteal phase. Following conception, this increase continued such that a 45% mean increase was evident by the 9th wk of gestation. In 2 women who aborted spontaneously, the change in 24 h creatinine clearance in early pregnancy was not as great nor as sustained; this feature was apparent at least 3 wk before any clinical abnormality. Possible reasons for the changes in glomerular filtration rate in early pregnancy and its clinical implications are discussed.