Abnormal brain structure in children with isolated clefts of the lip or palate
Abnormal brain structure in children with isolated clefts of the lip or palate
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DOI：
10.1001/archpedi.161.8.753
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发表时间：
2007-08-01
影响因子：
--
通讯作者：
Richman, Lynn
中科院分区：
文献类型：
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作者：
Nopoulos, Peg;Langbehn, Douglas R.;Richman, Lynn
目的：为了评估大脑结构的一个样本的儿童孤立唇腭裂和/或palate（ICLP. Design：病例对照研究。设置：三级保健center.Participants：一个大样本的74名儿童年龄在7至17岁的ICLP与健康对照组进行了比较，匹配的年龄和性别。//主要暴露：孤立性唇腭裂。结果测量：获得身高和头围的一般测量值。使用磁共振成像评估大脑结构，生成一般和局部脑测量值（体积）。结果：ICLP组的身高显著较低（F=4.83，P= 0.03）。在控制了这个较小的身体尺寸后，ICLP儿童的大脑和小脑都异常小（F = 4.47，P = 0.04）和（F = 14.56，P
Objective: To evaluate brain structure in a sample of children with isolated clefts of the lip and/or palate (ICLP).Design: Case-control study.Setting: Tertiary care center.Participants: A large sample of 74 children aged 7 to 17 years with ICLP was compared with a healthy control group, matched by age and sex. //Main Exposure: Isolated cleft lip and/or palate.Outcome Measures: General measures of height and head circumference were obtained. Brain structure was evaluated using magnetic resonance imaging, generating both general and regional brain measures (volumes).Results: Height was significantly lower in the ICLP group (F=4.83, P=.03). After controlling for this smaller body size, children with ICLP had abnormally small brains with both cerebrum (F = 4.47, P = .04) and cerebellum (F = 14.56, P