Involvement of prefrontal cortex in visual search
Involvement of prefrontal cortex in visual search
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DOI：
10.1007/s00221-007-0860-0
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发表时间：
2007-06-01
影响因子：
2
通讯作者：
Kennard, C.
中科院分区：
文献类型：
--
作者：
Anderson, E. J.;Mannan, S. K.;Kennard, C.
在一组分散注意力的物品中寻找目标物品的视觉搜索一直被证明与枕叶和顶叶皮层区域有关，但前额叶皮层不同区域的作用尚不清楚。在这里，我们使用功能磁共振成像来比较12名健康参与者在执行高效和低效的搜索任务时的大脑活动，其中目标可辨别性和分心项目的数量被操纵。匹配的基线条件被纳入控制任务的视觉和运动部分，允许与每种搜索类型相关的皮层活动被隔离。兴趣区域分析应用于前额叶皮层的关键区域，以确定它们的参与是高效搜索和低效搜索共同的，还是只有低效搜索才参与。我们发现下额叶皮层和中额叶皮层区域仅在低效搜索时活跃，而上额叶皮层（FEF区域）的一个区域在高效和低效搜索时都活跃。因此，腹侧和背侧前额叶皮层区域在低效搜索中被招募，我们认为这种活动与指导、控制和监测选择性注意力分配的过程有关。
Visual search for target items embedded within a set of distracting items has consistently been shown to engage regions of occipital and parietal cortex, but the contribution of different regions of prefrontal cortex remains unclear. Here, we used fMRI to compare brain activity in 12 healthy participants performing efficient and inefficient search tasks in which target discriminability and the number of distractor items were manipulated. Matched baseline conditions were incorporated to control for visual and motor components of the tasks, allowing cortical activity associated with each type of search to be isolated. Region of interest analysis was applied to critical regions of prefrontal cortex to determine whether their involvement was common to both efficient and inefficient search, or unique to inefficient search alone. We found regions of the inferior and middle frontal cortex were only active during inefficient search, whereas an area in the superior frontal cortex (in the region of FEF) was active for both efficient and inefficient search. Thus, regions of ventral as well as dorsal prefrontal cortex are recruited during inefficient search, and we propose that this activity is related to processes that guide, control and monitor the allocation of selective attention.