Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects
Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects
复制标题
DOI：
10.1002/adma.201502422
复制
发表时间：
2015-12-02
影响因子：
29.4
通讯作者：
Gaharwar, Akhilesh K.
中科院分区：
文献类型：
--
作者：
Chimene, David;Alge, Daniel L.;Gaharwar, Akhilesh K.
二维（2D）纳米材料是具有高度各向异性和化学功能性的纳米材料。2D纳米材料的研究仍处于起步阶段，大多数研究集中在阐明独特的材料特征，很少有报道关注2D纳米材料的生物医学应用。然而，最近在2D纳米材料的快速发展提出了重要的和令人兴奋的问题，它们与生物部分的相互作用。2D纳米颗粒如碳基2D材料、硅酸盐粘土、过渡金属二硫属化物（TMD）和过渡金属氧化物（TMO）由于其均匀的形状、高表面积与体积比和表面电荷而提供增强的物理、化学和生物功能性。在这里，我们专注于2D纳米材料的最新生物医学应用以及正在塑造这一新兴领域的最新发展。具体来说，我们描述了使2D纳米颗粒如此有价值的独特特性，以及迄今为止已经研究的生物相容性框架。最后，为了捕捉2D纳米材料在生物医学应用中的增长趋势，并确定有前途的新研究方向，我们对最近开发的2D纳米材料的潜在应用进行了严格的评估。
Two-dimensional (2D) nanomaterials are ultrathin nanomaterials with a high degree of anisotropy and chemical functionality. Research on 2D nanomaterials is still in its infancy, with the majority of research focusing on elucidating unique material characteristics and few reports focusing on biomedical applications of 2D nanomaterials. Nevertheless, recent rapid advances in 2D nanomaterials have raised important and exciting questions about their interactions with biological moieties. 2D nanoparticles such as carbon-based 2D materials, silicate clays, transition metal dichalcogenides (TMDs), and transition metal oxides (TMOs) provide enhanced physical, chemical, and biological functionality owing to their uniform shapes, high surface-to-volume ratios, and surface charge. Here, we focus on state-of-the-art biomedical applications of 2D nanomaterials as well as recent developments that are shaping this emerging field. Specifically, we describe the unique characteristics that make 2D nanoparticles so valuable, as well as the biocompatibility framework that has been investigated so far. Finally, to both capture the growing trend of 2D nanomaterials for biomedical applications and to identify promising new research directions, we provide a critical evaluation of potential applications of recently developed 2D nanomaterials.