The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
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DOI：
10.1038/modpathol.3800721
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发表时间：
2007-01-01
期刊：
影响因子：
7.5
通讯作者：
Dabbs, David J.
中科院分区：
文献类型：
--
作者：
Esposito, Nicole N.;Chivukula, Mamatha;Dabbs, David J.
小叶小管癌是一种混合了浸润性小管和小叶样细胞的乳腺癌。以前的报道显示它与小叶癌有临床相似性，而最近的研究显示它是E-钙粘蛋白阳性。当前研究的目的是进一步探索小管状小叶癌的免疫表型，并记录其自然行为。本文收集了19例小管小叶癌和10例小管小叶癌进行对比分析。用抗雌激素受体、孕激素受体、HER 2/neu、34 bE 12、E-钙粘蛋白和连环蛋白的抗体进行免疫组织化学。25%的管状小叶癌患者表现为大于I期疾病，而管状和小叶癌患者分别为0和60%。2例小管小叶癌患者出现肿瘤复发，其中1例还出现转移。所有癌中大多数为雌激素和孕激素受体阳性。上皮钙粘蛋白在所有管状和管状小叶癌中呈膜性染色，在所有小叶癌中均为阴性。每种癌亚型的一半显示颗粒状胞质34 bE 12免疫反应性。α-连环蛋白在所有的小管状癌和管状癌中表现出部分或完全的膜染色，而在所有的小叶癌中均为阴性。β-连环蛋白在小叶和管状癌中显示膜染色，而所有小叶癌的胞质免疫反应性较粗。p120和c-catenin在100%的小管状癌和管状癌中呈膜染色，在100%的小叶癌中呈胞浆染色。因此，乳腺管小叶癌是一种独特类型的乳腺癌，其组织学上显示管状和小叶模式，但显示导管免疫表型特征的膜E-钙粘蛋白/连环蛋白复合物。虽然平均随访40个月时所有患者均存活，但由于16%的患者有淋巴结转移，因此小叶小管癌似乎比管状癌更具侵袭性。
Tubulolobular carcinoma is a type of mammary carcinoma that displays an admixture of invasive tubules and lobular-like cells. Previous reports have shown it to share clinical similarities to lobular carcinoma, whereas more recent studies have shown it to be E-cadherin positive. The aim of the current study was to further explore the immunophenotype of tubulolobular carcinoma, and to document its natural behavior. Nineteen cases of tubulolobular carcinoma and 10 cases each of tubular and lobular carcinoma were retrieved for comparison analysis. Immunohistochemistry was performed with antibodies against estrogen receptor, progesterone receptor, HER2/neu, 34bE12, E-cadherin, and the catenins. Twenty-five percent of patients with tubulolobular carcinoma presented with greater than stage I disease, compared to 0 and 60% of patients with tubular and lobular carcinoma, respectively. Two patients with tubulolobular carcinoma had tumor recurrence, one of whom also developed metastasis. The majority of all carcinomas were estrogen and progesterone receptor positive. E-cadherin displayed membranous staining in all tubular and tubulolobular carcinomas, and was negative in all lobular carcinomas. Half of each carcinoma subtype displayed granular cytoplasmic 34bE12 immunoreactivity. alpha-Catenin exhibited partial or complete membranous staining in all tubulolobular and tubular carcinomas, and was negative in all lobular carcinomas. beta-Catenin displayed membranous staining in tubulolobular and tubular carcinomas, whereas all lobular carcinomas had coarse cytoplasmic immunoreactivity. p120 and c-catenin displayed membranous staining in 100% of tubulolobular and tubular carcinomas and cytoplasmic staining in 100% of lobular carcinomas. Tubulolobular carcinoma of the breast is thus a distinct type of mammary carcinoma that displays both tubular and lobular patterns histologically but displays the membranous E-cadherin/catenin complex characteristic of the ductal immunophenotype. Tubulolobular carcinoma appears to be more aggressive than tubular carcinoma, as 16% of patients had lymph node metastases, although all were alive at a mean follow-up of 40 months.