A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates
A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates
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DOI：
10.1016/j.ijantimicag.2004.10.016
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发表时间：
2005-06-01
影响因子：
10.8
通讯作者：
Vila, J
中科院分区：
文献类型：
--
作者：
Ruiz, J;Moreno, A;Vila, J
本研究的目的是比较不同的氟喹诺酮类药物对弯曲杆菌属，分析抗药性的分子机制。莫西沙星表现出最大的活性的喹诺酮类药物测试，积极对分离携带单一突变的gyrA基因。高水平的耐药水平与双gyrA突变的存在有关。(c)2005年Elsevier B.V.和国际化疗学会。All rights reserved.
The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.