Unique white matter structural connectivity in early-stage drug-naive Parkinson disease
Unique white matter structural connectivity in early-stage drug-naive Parkinson disease
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DOI：
10.1212/wnl.0000000000008867
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发表时间：
2020-02-25
期刊：
影响因子：
9.9
通讯作者：
Walsh, Ryan R.
中科院分区：
文献类型：
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作者：
Mishra, Virendra R.;Sreenivasan, Karthik R.;Walsh, Ryan R.
目的探讨早期未用药帕金森病（PD）患者全脑白色物质（WM）结构连接的拓扑结构和强度。方法采用无模型数据驱动的方法，利用弥散MRI技术计算70例早期未用药PD患者和41例健康对照者的全脑WM拓扑结构和脑区之间的连接强度。随后，我们通过最小化每组解剖连接的方差来生成一种新的组特异性WM解剖网络。全球WM连接强度和网络措施计算组特异性WM解剖网络，并进行组间比较。我们测试了这些网络措施的相关性与PD的临床措施，以评估其病理生理学relevance. ResultsPD相关的皮质和皮质下区域被确定在新的PD特异性WM解剖网络。受损的模块化组织伴随着网络措施与多个临床变量在早期PD的相关性被揭示。此外，疾病的持续时间呈负相关，全球连接强度的PD-特定的WM解剖network.ConclusionBy最小化变异的解剖连接，本研究发现存在一种新的WM结构连接体在早期PD与临床症状相关，尽管缺乏先验的分析假设。这包括已知PD相关脑区之间结构连接性增加的新发现。目前的研究为进一步研究帕金森病的临床和病理异质性的WM结构变化提供了一个框架。
ObjectiveTo investigate the topographic arrangement and strength of whole-brain white matter (WM) structural connectivity in patients with early-stage drug-naive Parkinson disease (PD).MethodsWe employed a model-free data-driven approach for computing whole-brain WM topologic arrangement and connectivity strength between brain regions by utilizing diffusion MRI of 70 participants with early-stage drug-naive PD and 41 healthy controls. Subsequently, we generated a novel group-specific WM anatomical network by minimizing variance in anatomical connectivity of each group. Global WM connectivity strength and network measures were computed on this group-specific WM anatomical network and were compared between the groups. We tested correlations of these network measures with clinical measures in PD to assess their pathophysiologic relevance.ResultsPD-relevant cortical and subcortical regions were identified in the novel PD-specific WM anatomical network. Impaired modular organization accompanied by a correlation of network measures with multiple clinical variables in early PD were revealed. Furthermore, disease duration was negatively correlated with global connectivity strength of the PD-specific WM anatomical network.ConclusionBy minimizing variance in anatomical connectivity, this study found the presence of a novel WM structural connectome in early PD that correlated with clinical symptoms, despite the lack of a priori analytic assumptions. This included the novel finding of increased structural connectivity between known PD-relevant brain regions. The current study provides a framework for further investigation of WM structural changes underlying the clinical and pathologic heterogeneity of PD.