TEMPERATURE DEPENDENT BEHAVIOR OF ULTRASOUND CONTRAST AGENTS
TEMPERATURE DEPENDENT BEHAVIOR OF ULTRASOUND CONTRAST AGENTS
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DOI：
10.1016/j.ultrasmedbio.2010.03.003
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发表时间：
2010-06-01
影响因子：
2.9
通讯作者：
Eckersley, Robert J.
中科院分区：
文献类型：
--
作者：
Mulvana, Helen;Stride, Eleanor;Eckersley, Robert J.
最近对超声造影剂（UCAs）作为定量成像和治疗工具的兴趣增加了对准确表征的需求。实验室调查经常在室温下的水浴中进行；然而，对体内应用的影响并没有提出。在温度为20-45℃的水浴中对SonoVue （Bracco Research, Geneva, Switzerland）的体悬浮液进行声学研究，UCA特性受到温度的显著影响，特别是在20- 40℃之间，导致衰减分别从1.7-2.5 dB增加（p = 0.002），在相同范围内，在100 kPa的超声压力下，散射信号增加2 dB （p = 0.05）。光学数据支持了温度介导的直径增加是主要原因的假设，并揭示了气泡稳定性的降低。总之，在室温下进行的测量需要仔细解释体内的行为。（E-mail: h.mulvana@imperial.ac.uk） (C) 2010年世界超声医学与生物学联合会。
Recent interest in ultrasound contrast agents (UCAs) as tools for quantitative imaging and therapy has increased the need for accurate characterization. Laboratory investigations are frequently undertaken in a water bath at room temperature; however, implications for in vivo applications are not presented. Acoustic investigation of a bulk suspension of SonoVue (Bracco Research, Geneva, Switzerland) was made in a water bath at temperatures of 20-45 degrees C. UCA characteristics were significantly affected by temperature, particularly between 20 and 40 degrees C, leading to an increase in attenuation from 1.7-2.5 dB, respectively (p = 0.002) and a 2-dB increase in scattered signal over the same range (p = 0.05) at an insonation pressure of 100 kPa. Optical data supported the hypothesis that a temperature-mediated increase in diameter was the dominant cause, and revealed a decrease in bubble stability. In conclusion, measurements made at room temperature require careful interpretation with regard to behavior in vivo. (E-mail: h.mulvana@imperial.ac.uk) (C) 2010 World Federation for Ultrasound in Medicine & Biology.