Physiological Responses of Local Areas of the Cerebral Circulation in Experimental Primates Determined by the Method of Hydrogen Clearance
Physiological Responses of Local Areas of the Cerebral Circulation in Experimental Primates Determined by the Method of Hydrogen Clearance
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氢清除法测定实验灵长类脑循环局部区域的生理反应
DOI：
10.1161/01.str.4.4.632
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发表时间：
1973
期刊：
影响因子：
8.3
通讯作者：
N. Branston
中科院分区：
文献类型：
--
作者：
L. Symon;Emil Pasztor;N. Dorsch;N. Branston
已经评估了皮质、壳核和白色物质对动脉CO2张力变化的反应性。三种组织获得的CO2反应性之间无显著差异，每mm Hg PCO2增加，基础血流量增加2%至3.5%。数据表明，白色物质的反应性略高于灰质，但差异不显著。在皮质和壳核灰质以及白色物质中发现了对由出血或脑池灌注引起的颅内压升高引起的灌注压改变的良好的自动调节。随着两种技术灌注压的降低，白色物质比灰质更容易诱导零血流。通过两种方法获得的灌注压变化的自动调节曲线似乎是相同的，这表明在动脉压降低或颅内压升高时维持脑血流的机制是相同的。在降低一段时间后灌注压恢复后，在检查的所有三个脑循环区域中观察到充血。在这三个部位，相似刺激引起的充血程度无显著差异。
The reactivity of cortex, putamen and white matter to changes in arterial CO2 tension has been assessed. There was no significant difference between the CO2 reactivity obtained for the three tissues which were in the region of 2% to 3.5% increase over basal blood flow per mm Hg PCO2 increase. The data suggested a somewhat greater reactivity for white matter than for gray matter, though differences were not significant. Excellent autoregulation to altered perfusion pressure, induced either by hemorrhage or by raising the intracranial pressure with cisternal infusion, was found in gray matter of cortex and putamen and in white matter. With reduction of perfusion pressure by both techniques, it appeared that zero blood flow could be more readily induced in white matter than in gray matter. Autoregulatory curves to change in perfusion pressure obtained by either method seemed identical, suggesting that the mechanisms involved in the maintenance of cerebral blood flow in the face of reduced arterial pressure or rising intracranial pressure are the same. Hyperemia was observed in all three areas of the cerebral circulation examined following the restoration of perfusion pressure after a period of reduction. No significant differences in the degree of hyperemia induced by similar stimuli were observed in these three sites.