Human circulating monocytes as multipotential progenitors
Human circulating monocytes as multipotential progenitors
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DOI：
10.2302/kjm.56.41
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发表时间：
2007-06-01
影响因子：
2
通讯作者：
Kuwana, Masataka
中科院分区：
文献类型：
--
作者：
Seta, Noriyuki;Kuwana, Masataka
循环单核细胞被认为是巨噬细胞和树突状细胞等吞噬细胞的前体。最近，我们报道了一个原始的人类细胞群称为单核细胞衍生的多能细胞（MOMC），它具有成纤维细胞样的形态和独特的表型阳性的CD 14，CD 45，CD 34，和I型胶原。这种新的细胞类型表现出单核细胞、内皮细胞和间充质细胞的混合形态和表型特征。MOMC来源于循环的CD 14（+）单核细胞，其分化需要与纤连蛋白结合并暴露于一种或多种来源于外周血CD 14（-）细胞的可溶性因子。MOMC含有能够分化成各种非吞噬细胞的祖细胞，包括骨、软骨、脂肪、骨骼肌和心肌、神经元和内皮。其他人最近的研究也描述了几种不同的人细胞群，它们来源于循环单核细胞，并具有分化为非吞噬细胞的能力。这些观察结果共同表明，循环单核细胞比以前认为的更具多能性。此外，使用循环单核细胞的细胞移植疗法是组织再生的潜在方法。
Circulating monocytes are believed to be committed precursors for phagocytes, such as macrophages and dendritic cells. Recently, we have reported a primitive human cell population called monocyte-derived multipotential cells (MOMC), which has a fibroblastlike morphology and a unique phenotype positive for CD14, CD45, CD34, and type I collagen. This novel cell type exhibits mixed morphologic and phenotypic features of monocytes, endothelial cells, and mesenchymal cells. MOMC are derived from circulating CD14(+) monocytes, and their differentiation requires binding to fibronectin and exposure to one or more soluble factors derived from peripheral blood CD14(-) cells. MOMC contain progenitors with capacity to differentiate into a variety of non-phagocytes, including bone, cartilage, fat, skeletal and cardiac muscle, neuron, and endothelium. Recent studies by others have also described several distinct human cell populations that are originated from circulating monocytes and have capacity to differentiate into non-phagocytes. These observations together indicate that circulating monocytes are more multipotential than previously thought. In addition, cell transplantation therapies using circulating monocytes are a potential approach for tissue regeneration.