The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances.
The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances.
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DOI：
10.1007/s11010-023-04853-6
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发表时间：
2023-10
影响因子：
4.3
通讯作者：
Songlin Li;Linna Zhao;Jie Xiao;Yuying Guo;Rong Fu;Yunsha Zhang;Shixin Xu
中科院分区：
文献类型：
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作者：
Songlin Li;Linna Zhao;Jie Xiao;Yuying Guo;Rong Fu;Yunsha Zhang;Shixin Xu
肠道和大脑之间存在复杂的相互作用。随着对肠道菌群与大脑功能之间关系的研究不断增多，积累的临床和临床前证据表明肠道菌群与神经退行性疾病（ND）的发病机制密切相关。越来越多的研究开始关注肠道微生物群与中枢神经系统 (CNS) 退行性病变之间的关联，以寻找这些难治性疾病的潜在疗法。在这篇综述中，我们总结了阿尔茨海默病、帕金森病、多发性硬化症和肌萎缩侧索硬化症中肠道微生物群的变化，有助于我们了解肠道微生物群在 ND 中的功能及其可能参与的发病机制。随后我们讨论了针对这些疾病中肠道微生物异常的治疗方法，包括抗生素、饮食、益生菌和粪便微生物移植（FMT）。此外，我们总结了一些已完成和正在进行的肠道微生物干预NDs的临床试验，这可能为NDs的研究提供新的思路。
There are complex interactions between the gut and the brain. With increasing research on the relationship between gut microbiota and brain function, accumulated clinical and preclinical evidence suggests that gut microbiota is intimately involved in the pathogenesis of neurodegenerative diseases (NDs). Increasingly studies are beginning to focus on the association between gut microbiota and central nervous system (CNS) degenerative pathologies to find potential therapies for these refractory diseases. In this review, we summarize the changes in the gut microbiota in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis and contribute to our understanding of the function of the gut microbiota in NDs and its possible involvement in the pathogenesis. We subsequently discuss therapeutic approaches targeting gut microbial abnormalities in these diseases, including antibiotics, diet, probiotics, and fecal microbiota transplantation (FMT). Furthermore, we summarize some completed and ongoing clinical trials of interventions with gut microbes for NDs, which may provide new ideas for studying NDs.