Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea
Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea
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DOI：
10.1016/j.canlet.2004.08.014
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发表时间：
2004-12-28
期刊：
影响因子：
9.7
通讯作者：
Kono, S
中科院分区：
文献类型：
--
作者：
Kim, DH;Ahn, YO;Kono, S
一些但不是所有的研究报道了5，10-亚甲基四氢叶酸还原酶（MTHFR）多态性（C677 T）的变异基因型（MTHFR是叶酸代谢中的一种酶）与结直肠癌风险降低相关。本研究采用病例对照研究方法，探讨韩国人MTHFR基因多态性和大量饮酒与结直肠癌的关系。病例是1998年至2000年期间在韩国首尔的两所大学医院住院的经组织学证实的偶发结肠直肠癌患者的连续系列，对照组在相同的医院选择。共纳入243例（结肠111例，直肠132例）和225例对照。虽然MTHFR基因型与结直肠癌的总体风险无关，但发现与野生型相比，CT和TT基因型合并后结肠癌风险增加（多变量比值比[OR] 2.01，95%置信区间[CI] 1.143.53）。尽管在统计学上无显著性，但发现CT和TT基因型组合的患者患直肠癌的风险较低（多变量OR 0.67，95%CI：0.43-1.07）。那些每天饮酒两次或两次以上（30 g +/天）的人患结肠直肠癌的风险（多变量OR 1.94，95% CI 1.03-3.68）几乎是轻度或非饮酒者的两倍（
Several, but not all, studies have reported that a variant genotype of the polymorphism (C677T) of 5,10-methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, is associated with a decreased risk of colorectal cancer. A case-control study was conducted to investigate the association of MTHFR polymorphism and heavy alcohol intake to colon and rectal cancer in Korean. Cases were a consecutive series of patients with histologically confirmed, incident colorectal cancer who were admitted to two university hospitals in Seoul, Korea between 1998 and 2000, and controls were selected at the same hospitals. A total of 243 cases (colon 111, rectum 132) and 225 controls were enrolled. While the genotype of MTHFR was not associated with the overall risk of colorectal cancer, increased colon cancer risk was found to be associated with the CT and TT genotypes combined (multivariate odds ratio [OR] 2.01, 95% confidence interval [CI] 1.143.53) compared with the wild type. The risk of rectal cancer was found to be, though statistically non-significant, lower in those with the CT and TT genotypes combined (multivariate OR 0.67, 95% CI: 0.43-1.07). Those consuming two or more drinks per day (30 g +/day) had nearly twice the colorectal cancer risk (multivariate OR 1.94, 95% CI 1.03-3.68) of light or non-drinkers (