Paraproteinemia, plasmacytoma, myeloma and HIV infection
Paraproteinemia, plasmacytoma, myeloma and HIV infection
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DOI：
10.1038/sj.leu.2400875
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发表时间：
1997-12-01
期刊：
影响因子：
11.4
通讯作者：
Atac, B
中科院分区：
文献类型：
--
作者：
Fiorino, AS;Atac, B
我们通过MEDLINE检索确定了英文文献中报告的HIV阳性患者中的丙种球蛋白病和浆细胞恶性肿瘤病例，HIV阳性浆细胞疾病患者的平均就诊年龄为33岁，远低于一般人群的平均就诊年龄。这些患者中的一些表现为短暂的副蛋白血症，而另一些则有持续的副蛋白，这可能与真正的浆细胞恶性肿瘤有关，也可能无关。在大多数情况下，它已被检查，副蛋白含有高滴度抗HIV活性。在艾滋病患者的副蛋白中存在高滴度抗HIV活性表明，对HIV感染的抗原驱动过程可能有助于这些患者中浆细胞疾病的早期发展。浆细胞肿瘤发生的最新研究表明，B淋巴细胞谱系中的单个点的转化可以产生淋巴瘤或骨髓瘤，这取决于环境因素如T细胞功能，T细胞功能可能是引导转化的淋巴细胞从淋巴瘤向浆细胞分化所必需的。这可以解释为什么艾滋病患者的B系肿瘤发生倾向于淋巴瘤而不是骨髓瘤。
We have identified by MEDLINE search the cases of gammaglo-binopathy and plasma cell malignancy in HIV-positive patients reported in the English language literature, The average age at presentation among HIV-positive patients with plasma cell disorders is 33 years, far younger than the average age of presentation in the general population. Some of these patients present with transient paraproteinemias, while others have persistent paraproteins, which may or may not be associated with true plasma cell malignancies. In most cases in which it has been examined, the paraprotein contains high-titer anti-HIV activity. The presence of high titer anti HIV activity in the paraproteins of AIDS patients suggests that an antigen-driven process in response to HIV infection may contribute to the early development of plasma cell disorders in these patients. Recent work In plasma cell tumorigenesis has indicated that transformation at a single point in the B lymphocyte lineage can give rise to either lymphoma or myeloma, dependent upon environmental factors such as T cell function, which may be required for directing transformed lymphocytes from lymphoma and towards plasma cell differentiation. This may explain why B lineage oncogenesis in AIDS patients favors the development of lymphoma over that of myeloma.