Contributions of Tryptophan 2,3-dioxygenase and Indoleamine 2,3-dioxygenase to the Conversion of D-Tryptophan to Nicotinamide Analyzed by using Tryptophan 2,3-dioxygenase -Knockout Mice
Contributions of Tryptophan 2,3-dioxygenase and Indoleamine 2,3-dioxygenase to the Conversion of D-Tryptophan to Nicotinamide Analyzed by using Tryptophan 2,3-dioxygenase -Knockout Mice
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使用色氨酸 2,3-双加氧酶敲除小鼠分析色氨酸 2,3-双加氧酶和吲哚胺 2,3-双加氧酶对 D-色氨酸转化为烟酰胺的贡献
DOI：
10.1080/09168451.2014.905185
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Shibata K
中科院分区：
文献类型：
--
作者：
Maeta A;Sano M;Fukuwatari T;Funakoshi H;Nakamura T;Shibata K
我们研究了色氨酸2，3-双加氧酶（TDO）和吲哚胺2，3-双加氧酶（IDO）在TDO基因敲除小鼠中对d-色氨酸转化为烟酰胺的贡献百分比。计算的转化百分比表明TDO和IDO分别氧化70%和30%的二芳基-色氨酸。这些结果表明TDO和IDO在小鼠中均由d-色氨酸和l-色氨酸生物合成烟酰胺。
We investigated the contribution percentage of tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) to the conversion ofd-tryptophan to nicotinamide in TDO-knockout mice. The calculated percentage conversions indicated that TDO and IDO oxidized 70 and 30%, respectively, of the dietaryl-tryptophan. These results indicate that both TDO and IDO biosynthesize nicotinamide fromd-tryptophan andl-tryptophan in mice.