Porphyrin-based compounds exert antibacterial action against the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi
Porphyrin-based compounds exert antibacterial action against the sexually transmitted pathogens Neisseria gonorrhoeae and Haemophilus ducreyi
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DOI：
10.1016/j.ijantimicag.2004.06.008
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发表时间：
2004-12-01
影响因子：
10.8
通讯作者：
Stojilikovic, I
中科院分区：
文献类型：
--
作者：
Bozja, J;Yi, K;Stojilikovic, I
一系列不含金属(NMP)或含金属(MP)的卟啉化合物在体外对性传播病原体淋球菌和杜热氏嗜血杆菌有较强的杀菌作用。NMP和MP对5种乳杆菌均无杀菌活性。在小鼠阴道模型中，含有镓的MP具有阻断淋球菌感染的能力，这表明它作为一种局部杀菌剂来阻断性传播细菌感染是有必要的。与其他细菌物种相比，hpuB编码的淋球菌血红蛋白摄取系统的丧失或通过TonB-ExbB-ExbD系统提供的能量的丧失对淋球菌的NIP敏感性水平没有显著影响。相反，淋球菌失活mtrCDE编码的外排泵的突变被发现增加了淋球菌对NMPS和MPS的敏感性，而这种外排泵的过度产生降低了淋球菌对这些化合物的敏感性水平。(C)2003年Elsevier B.V.和国际化疗学会。版权所有。
A series of porphyrin based compounds without (nMP) or with (MP) metals were found to have potent bactericidal action in vitro against the sexually transmitted pathogens Neisseria gonorrhoaeae and Haemophilus ducreyi. nMP and MP did not show bactericidal activity against five species of lactobacilli. An MP containing gallium had the capacity to block a gonococcal infection in a murine vaginal model, indicating that its development as a topical microbicide to block sexually transmitted bacterial infections is warranted. In contrast to other bacterial species, loss of the gonococcal haemoglobin uptake system encoded by hpuB or energy supplied through the TonB-ExbB-ExbD system did not significantly affect levels of NIP-susceptibility in gonococci. In contrast, mutations in gonococci that inactivate the mtrCDE-encoded efflux pump were found to enhance gonococcal susceptibility to nMPs and MPs while over-production of this efflux pump decreased levels of gonococcal susceptibility to these compounds. (C) 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.