Morphogenesis of the human lacrimal gland
Morphogenesis of the human lacrimal gland
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DOI：
10.1046/j.1469-7580.2003.00233.x
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发表时间：
2003-11-01
影响因子：
2.4
通讯作者：
Mérida-Velasco, JR
中科院分区：
文献类型：
--
作者：
de la Cuadra-Blanco, C;Peces-Peña, MD;Mérida-Velasco, JR
本研究的目的是确定人类泪腺发育过程的主要阶段，并建立其精确的形态发生时间表。其发病通常被认为发生在O' rahilli期21，由临时结膜穹窿上端上皮增厚引起。然而，目前的研究指出了这一过程的一个较早阶段：O' rahilly19期胚胎中上皮-间充质变化的存在。该研究使用光学显微镜对37个人类标本的连续切片进行了研究：23个胚胎和14个胎儿，冠臀长度为15至137毫米（发育7-116周）。泪腺形态发生分为三个阶段：(1)假定为腺状期，O' rahillys期19-20，特征为上穹窿上皮增厚，周围间质凝结；芽期，通常被认为是腺体起源的第一个表现，最初的特征是在结膜上穹窿区域出现结节状形成，最后在上皮芽内出现腔；(3)腺体成熟期，9-16周，腺体开始呈现成年形态。
The aim of this study was to determine the main stages of the lacrimal gland's developmental process in humans and to establish its precise morphogenetic timetable. its onset is generally assumed to take place at O'Rahilly's stage 21, arising from an epithelial thickening of the superior extreme of the temporary conjunctival fornix. However, the present study points to a prior stage in the process: the presence of epithelial-mesenchymal changes in embryos at O'Rahilly's stage 19. The study was performed using light microscopy on serial sections of 37 human specimens: 23 embryos and 14 fetuses ranging from 15 to 137 mm crown-rump length (7-116 weeks of development). Three stages in lacrimal gland morphogenesis were identified: (1) the presumptive glandular stage, O'Rahilly's stages 19-20, characterized by a thickening of the superior fornix epithelium together with surrounding mesenchymal condensation; (2) the bud stage, generally assumed to be the first manifestation of glandular origin, characterized initially by the appearance of nodular formations in the region of the superior conjunctival fornix and concluding with the appearance of lumina within the epithelial buds; and (3) the glandular maturity stage, weeks 9-16, the period in which the gland begins to take on the morphology of adulthood.