Thrombin-induced endothelial cell dysfunction.
Thrombin-induced endothelial cell dysfunction.
复制标题
凝血酶诱导的内皮细胞功能障碍。
作者：
M. Rabiet;J. Plantier;E. Dejana
内皮细胞是一种多功能器官，可以直接影响循环血液成分以及血管壁内的其他细胞。在受损内皮表面产生的凝血酶凝血酶诱导血液凝固，但也对内皮本身发挥各种功能作用。凝血酶作用于内皮细胞以刺激各种试剂的合成和释放，例如炎症介质、血管活性物质和生长因子。它通过触发细胞表面上粘附分子的表达而引起白细胞粘附于内皮，并引起内皮渗透性的破坏。凝血酶对内皮细胞的大多数作用是由其受体介导的，并且需要其溶解活性。不同来源的内皮细胞对凝血酶的反应存在差异。一般来说，微血管内皮细胞似乎对这种酶特别敏感。凝血酶诱导的微血管功能障碍可能具有病理后果，并导致器官对炎症和缺血的反应。
Endothelium is a multifunctional organ which can directly influence circulating blood components as well as other cells within the vessel wall. The clotting enzyme thrombin, generated at the surface of damaged endothelium, induces blood coagulation but also exerts a variety of functional effects on the endothelium itself. Thrombin acts on endothelial cells to stimulate synthesis and release of various agents, such as inflammatory mediators, vasoactive substances and growth factors. It causes leukocyte adhesion to the endothelium by triggering expression of adhesion molecules on the cell surface and causes disruption of endothelial permeability properties. The majority of thrombin effects on endothelial cells are mediated by its receptor and require its lytic activity. Differences have been observed among the response to thrombin of endothelial cells of different origin. In general microvascular endothelial cells appear to be particularly sensitive to this enzyme. Thrombin induced microvascular dysfunction can have pathological consequences and contribute to organ reactions to inflammation and ischaemia.