Advanced gastric cancer with liver metastases successfully treated with S-1
Advanced gastric cancer with liver metastases successfully treated with S-1
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S-1 成功治疗晚期胃癌肝转移
DOI：
10.1007/s101470200049
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发表时间：
2002
影响因子：
3.3
通讯作者：
Y. Hirayama
中科院分区：
文献类型：
--
作者：
S. Watanabe;T. Tanaka;T. Takeuchi;H. Takabayashi;Y. Hirayama
摘要。S-1是一种抗癌药物，其中替加富与调节剂、吉美拉西和奥他拉西钾联合使用。我们遇到了一位口服S-1有效的胃癌患者，我们报告了这个病例。一名79岁妇女来我院就诊，主诉为厌食症。检查显示严重贫血，血红蛋白（Hb）水平为6.5 g/dl，患者被送入医院治疗。原发病变为位于胃体中部的大1型胃癌（低分化腺癌）。左侧肝叶见直径约50 mm病灶，右侧肝叶散在可见小转移灶。当全身状况改善后，性能状态（PS）为0时，开始S-1治疗，剂量为80 mg/天（一个疗程，给药4周，休息2周）。未见严重药物不良反应。完成一个疗程后，患者在门诊接受治疗。两个疗程结束后，CT显示转移灶消失，原发灶明显消退。目前，第六疗程结束后，未见肝转移，胃原发病变有消退的趋势。她的PS保持在0。
Abstract. S-1 is an anticancer drug in which tegafur is combined with modulators, gimeracil and oteracil potassium. We encountered a patient with gastric cancer for whom oral administration of S-1 was effective, and we report this case. A 79-year-old woman visited our hospital with a major complaint of anorexia. Tests revealed severe anemia, with a hemoglobin (Hb) level of 6.5 g/dl, and the patient was admitted to the hospital for treatment. The primary lesion was a large type-1 gastric cancer (poorly differentiated adenocarcinoma) in the middle gastric body. In addition, a lesion with a diameter of 50 mm was observed in the left hepatic lobe and small metastatic lesions were also scattered in the right lobe. When a performance status (PS) of 0 was obtained after her systemic condition had been improved, S-1 was started, at a dose of 80 mg/day (with one course consisting of administration for 4 weeks, followed by 2 weeks' rest). No severe adverse drug reaction was observed. After one course of administration was completed, the patient received administrations at the outpatient clinic. Upon the completion of two courses, computed tomography (CT) showed disappearance of the metastatic lesions and marked regression of the primary lesion. At present, upon completion of the sixth course, no hepatic metastasis is observed and the primary gastric lesion shows a tendency to regress. Her PS is maintained at 0.