Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)
Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)
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DOI：
10.1046/j.1469-7580.2000.19740571.x
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发表时间：
2000-11-01
影响因子：
2.4
通讯作者：
Burgering, BMT
中科院分区：
文献类型：
--
作者：
Kops, GJPL;Burgering, BMT
在发现原癌基因蛋白激酶B（PKB）作为磷脂酰肌醇3'-激酶（PI3 - 激酶）信号传导的下游元件发挥作用之后（伯格林和科弗，1995年），已表明PKB介导多种PI3 - 激酶依赖性细胞反应。最近，已证实叉头转录因子家族3个成员的PKB依赖性磷酸化在PI3 - 激酶对转录的依赖性影响中起作用。这篇综述重点关注PKB在传递PI3 - 激酶依赖性细胞反应多样性方面新发现的功能。
Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.