Should safety of the flu vaccine for cancer patients be reexamined
Should safety of the flu vaccine for cancer patients be reexamined
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DOI：
10.12688/f1000research.13428.1
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
S. Paessler;V. Veljkovic
中科院分区：
文献类型：
--
作者：
S. Paessler;V. Veljkovic
建议接种季节性流感疫苗作为癌症患者预防流感感染的最佳保护措施。最近的计算机模拟和实验数据表明，流感疫苗引发的抗体可以激活缓激肽受体 B2 相关信号通路，该信号通路也参与细胞增殖和肿瘤细胞迁移。这些结果表明迫切需要重新审查流感疫苗在癌症患者中的安全性。
Seasonal flu vaccine is recommended as the best protection for cancer patients against influenza infection. Recent in silico and experimental data suggest that antibodies elicited with influenza vaccine could activate bradykinin receptor B2-associated signaling pathway, which is also involved in cell proliferation and migration of tumor cells. These results point to an urgent need for the reexamination of safety of influenza vaccine(s) in cancer patients.