The Growing Epidemic of Opioid Use Disorder in the Elderly and Its Treatment: A Review of the Literature.
The Growing Epidemic of Opioid Use Disorder in the Elderly and Its Treatment: A Review of the Literature.
复制标题
老年人阿片类药物使用障碍的流行及其治疗：文献综述。
DOI：
10.4088/pcc.21r03223
复制
发表时间：
2023
影响因子：
--
通讯作者：
Roopa Sethi
中科院分区：
文献类型：
--
作者：
Jaya Sri Konakanchi;Roopa Sethi
目的：美国人口统计趋势显示，65岁至65岁的成年人比例不断增加，其中约有100万人患有阿片类药物使用障碍（OUD）。由于与年龄相关的疼痛综合征和合并症增加了副作用、过量用药和死亡的风险，OUD在这个年龄组中可能尤其成问题。本综述的目的是评估老年OUD （mod）药物治疗的安全性和有效性。
Objective: US demographic trends show an increasing proportion of adults aged > 65 years old, approximately 1 million of whom are living with an opioid use disorder (OUD). OUD may be particularly problematic in this age group due to age-related pain syndromes and comorbidities that increase the risk of side effects, overdose, and death. The objective of this review was to assess the safety and efficacy of medications for OUD (MOUD) in the elderly.
Data Sources: A systematic search of the literature in PubMed, CINAHL, MEDLINE, Embase, and Cochrane Library databases was conducted from January 1992 through October 2021. The following terms were used: elderly, older adults, opioid use disorder, opioid dependence, buprenorphine, methadone, and medication-assisted treatment.
Study Selection: The search yielded 633 results. After following PRISMA guidelines and careful manual exclusion, 13 studies were selected for the review. No studies examining use of buprenorphine were identified for MOUD.
Results: The application of methadone for MOUD in the elderly shows that use is limited by preexisting conditions such as cardiac conduction abnormalities, which are more prevalent in the elderly than in the general population. Buprenorphine and naltrexone have been documented to have fewer interactions and potentially lethal adverse effects compared to methadone.
Conclusion: Future studies should focus on the application of buprenorphine or naltrexone for MOUD in the elderly.