Special Issue: Circadian Rhythms and Age Related Disorder: How Does Aging Impact Mammalian Circadian Organization?
Special Issue: Circadian Rhythms and Age Related Disorder: How Does Aging Impact Mammalian Circadian Organization?
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DOI：
10.1002/adbi.202200219
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发表时间：
2022-11
期刊：
影响因子：
3.7
通讯作者：
Wei Xu;Xiaodong Li
中科院分区：
文献类型：
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作者：
Wei Xu;Xiaodong Li
衰老显著影响哺乳动物的昼夜节律。行为、内分泌和代谢节律的幅度和精度随着年龄的增长而下降。尽管视交叉上核的分子钟表现出强劲的振荡，但这与中央起搏器输出幅度的年龄相关下降相伴。外周时钟在衰老过程中也表现出强大的振荡，当外周组织中发生其他基因表达节律的广泛重编程时。分子钟与中枢性和外周性组织的下游节律之间的年龄相关解离表明，除了分子钟之外，还有其他机制参与介导衰老对昼夜节律组织的影响。本文综述了衰老对昼夜节律功能的影响，并强调了炎症反应增加在昼夜节律组织年龄相关变化中的潜在作用。
Aging significantly impacts circadian timing in mammals. The amplitude and precision of behavioral, endocrine, and metabolic rhythms decline with age. This is accompanied with an age-related decline in the amplitude of central pacemaker output, although the molecular clock in the suprachiasmatic nucleus exhibit robust oscillation. Peripheral clocks also exhibit robust oscillation during aging, when extensive reprogramming of other genes' expression rhythms occurs in peripheral tissues. The age-related dissociation between the molecular clock and downstream rhythms in both central and peripheral tissues indicates that mechanisms other than the molecular clock are involved in mediating the impact the aging on circadian organization. In this article, findings are reviewed on the impact of aging on circadian timing functions, and the potential role of increased inflammatory response in age-related changes in circadian organization is highlighted.