Serum hepcidin and prohepcidin concentrations in inflammatory bowel disease
Serum hepcidin and prohepcidin concentrations in inflammatory bowel disease
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DOI：
10.1097/meg.0b013e328343b885
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发表时间：
2011-03-01
影响因子：
2.1
通讯作者：
Kouroumalis, Elias A.
中科院分区：
文献类型：
--
作者：
Oustamanolakis, Pantelis;Koutroubakis, Ioannis E.;Kouroumalis, Elias A.
背景：贫血是炎症性肠病（IBD）的重要并发症。最近的数据表明hepcidin是贫血的主要介质，在铁稳态和代谢中起核心作用。本研究的目的是评估IBD患者血清中hepcidin及其原激素（prohepcidin）的水平，并与健康对照进行比较。方法选取100例IBD患者[溃疡性结肠炎（UC） 49例，克罗恩病（CD） 51例]和102例健康对照。用市售的酶联免疫吸附测定试剂盒测定血清hepcidin和前hepcidin水平。评估其与UC和CD的临床和实验室参数的关系。结果UC和CD患者的中位hepcidin水平均显著高于健康对照组（P < 0.0001）。IBD患者中位prohepcidin水平显著低于健康对照组（P = 0.03）。在单因素分析中，血清hepcidin与血红蛋白水平呈显著负相关（r = -0.36, P = 0.0003），而血清prohepcidin与血红蛋白水平呈正相关（r = 0.65, P < 0.0001）。IBD患者hepcidin （r = 0.34, P = 0.0007）和prohepcidin （r = -0.21, P = 0.04）与铁蛋白水平均存在显著相关性。血清hepcidin还与疾病活动性（UC, r = 0.36, P = 0.009）和c反应蛋白（r = 0.29, P = 0.004）相关。多变量分析后，血清hepcidin水平仍与铁蛋白（P = 0.0008）和疾病活动性（UC, P = 0.004）显著相关。结论与健康对照组相比，IBD患者血清hepcidin和hepcidin前水平明显改变。这一发现表明这两种激素在IBD贫血的发展中起着重要作用。[J] .中华胃肠病杂志，2003,19 (3):1 -2 (C) 2011。
Background Anemia is an important complication of inflammatory bowel disease (IBD). Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with IBD in comparison with healthy controls.Methods One hundred patients with IBD [49 ulcerative colitis (UC), 51 Crohn's disease (CD)] and 102 healthy controls were enrolled. Serum hepcidin and prohepcidin levels were measured by commercially available enzyme-linked immunosorbent assays kits. Their relationship with clinical and laboratory parameters of UC and CD was assessed.Results Median hepcidin levels were significantly higher in both patients with UC and patients with CD compared with healthy controls (P < 0.0001). Median prohepcidin levels were significantly lower in patients with IBD compared with healthy controls (P = 0.03). In the univariate analysis, serum hepcidin was significantly negatively correlated (r = -0.36, P = 0.0003), whereas serum prohepcidin was positively correlated (r = 0.65, P < 0.0001) with the hemoglobin levels. Significant correlations of both hepcidin (r = 0.34, P = 0.0007) and prohepcidin (r = -0.21, P = 0.04) with ferritin levels were found in patients with IBD. Serum hepcidin was also correlated with disease activity (for UC, r = 0.36, P = 0.009) and C-reactive protein (r = 0.29, P = 0.004). After multivariate analysis serum hepcidin levels remained significantly correlated with ferritin (P = 0.0008) and disease activity (for UC, P = 0.004).Conclusion Serum hepcidin and prohepcidin levels are significantly altered in patients with IBD compared with healthy controls. This finding suggests a substantial role of these two hormones in the development of anemia in IBD. Eur J Gastroenterol Hepatol 23: 262-268 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.