Bioinspired phospholipid polymer biomaterials for making high performance artificial organs
Bioinspired phospholipid polymer biomaterials for making high performance artificial organs
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DOI：
10.1016/s1468-6996(00)00012-7
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发表时间：
2000-01-01
影响因子：
5.5
通讯作者：
Ishihara, K.
中科院分区：
文献类型：
--
作者：
Ishihara, K.
受生物膜表面结构的启发，人们制备了新型的可与血液接触的高分子生物材料。即合成了侧链带有磷脂极性基团的聚合物2-甲基丙烯酰氧乙基磷酰胆碱（MPC）聚合物。当MPC聚合物与血液接触时，即使在不存在抗凝剂的情况下，MPC聚合物也可以有效地抑制表面诱导的凝块形成。这种现象是由于血浆蛋白的减少和吸附蛋白质变性的抑制，即MPC聚合物与血液组分的相互作用非常温和。由于MPC聚合物的分子结构易于通过改变单体单元及其组成来设计，因此可应用于人工器官和生物医学器件的表面改性，以改善血液和组织相容性。因此，MPC聚合物是用于制造高性能人造器官和生物医学装置以提供安全医学治疗的有用聚合物生物材料。(C)2000爱思唯尔科技有限公司版权所有。
Novel polymer biomaterials, which can be used in contact with blood, are prepared with strong inspiration from the surface structure of biomembrane. That is, the polymers with a phospholipid polar group in the side chain, 2-methacrylooyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, when they are in contact with blood even in the absence of an anticoagulant. This phenomenon was due to the reduction of plasma protein and suppression of denaturation of adsorbed proteins, that is the MPC polymers interact with blood components very mildly. As the molecular structure of the MPC polymer was easily designed by changing the monomer units and their composition, it could be applied to surface modification of artificial organs and biomedical devices for improving blood and tissue compatibility. Thus, the MPC polymers are useful polymer biomaterials for manufacturing high performance artificial organs and biomedical devices to provide safe medical treatments. (C) 2000 Elsevier Science Ltd. All rights reserved.