Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages.
Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages.
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体外和 C3H/Km 小鼠中 RIF-1 肿瘤对 X 辐射（细胞存活、再生延迟和肿瘤控制）、化疗药物和活化巨噬细胞的反应。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
S. Zamvil
中科院分区：
文献类型：
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作者：
J. Brown;P. Twentyman;S. Zamvil
发现对数生长期和进食平台期RIF-1细胞在体外的辐射响应的特征在于D 0（半对数图上的细胞存活曲线的斜率）值分别为110和133拉德，外推数分别为36和28。非麻醉小鼠体内肿瘤对X射线照射的反应表现出对肿瘤植入部位的依赖性。在腿部肌肉中，反应表明大多数细胞处于中等水平的氧合，而在侧腹的皮下组织中，肿瘤的反应表明它具有最大放射抗性的低氧细胞的一小部分（1.5%）。通过细胞存活和再生长延迟来测量米索硝唑对腿部植入肿瘤的放射增敏。小鼠的肿瘤治疗剂量中位数为3，990拉德（3，670 - 4，340），这与辐射存活曲线预测的结果非常一致。肿瘤对单剂量的1，3-双（2-氯乙基）-1-亚硝基脲相对不敏感，对单剂量的顺铂敏感，对单剂量的环磷酰胺高度敏感。
The radiation response of logarithmic growth phase and fed plateau phase RIF-1 cells in vitro was found to be characterized by D0 (slope of cell survival curve on semilog plot) values of 110 and 133 rads and extrapolation numbers of 36 and 28, respectively. The response of the tumor in vivo to X-irradiation in nonanesthetized mice showed a dependence on the tumor implantation site. In the leg muscle, the response indicated that most cells were at an intermediate level of oxygenation, whereas in the subcutaneous tissue of the flank, the response of the tumor indicated that it had a small fraction (1.5%) of hypoxic cells of maximum radioresistance. Misonidazole radiosensitized the leg-implanted tumor as measured both by cell survival and regrowth delay. The median tumor cure dose of radiation in mice was 3,990 rads (3,670--4,340), which agreed closely with that predicted from the radiation survival curve. The tumor was relatively insensitive to a single dose of 1,3-bis(2-chloroethyl)-1-nitrosourea, sensitive to a single dose of cis-platinum, and highly sensitive to a single dose of cyclophosphamide.