Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China
Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China
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DOI：
10.1086/430301
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发表时间：
2005-06-15
影响因子：
11.8
通讯作者：
Peiris, JSM
中科院分区：
文献类型：
--
作者：
Chiu, SS;Chan, KH;Peiris, JSM
背景人冠状病毒NL 63（Human coronavirus NL 63，HCoV-NL 63）是近年来发现的一种能引起儿童和成人呼吸道疾病的人冠状病毒，与严重急性呼吸综合征（SARS）冠状病毒、人冠状病毒229 E（Human Coronavirus 229 E，HCoV-229 E）和人冠状病毒OC 43（Human Coronavirus OC 43，HCoV-OC 43）不同。我们调查了2001年8月至2002年8月期间在香港因发热和急性呼吸道症状住院的儿童中HCoV-NL 63、HCoV-OC 43和HCoV-229 E的作用。在研究的587名儿童中，有26名（4.4%）检测到冠状病毒感染; 15名（2.6%）HCoV-NL 63阳性，9名（1.5%）HCoV-OC 43阳性，2名（0.3%）HCoV-229 E阳性。除了引起上呼吸道疾病外，我们发现HCoV-NL 63还可表现为哮吼、哮喘加重、热性惊厥和高烧。受感染儿童的平均年龄（±标准差[SD]）为30.7 ± 19.8个月（范围，6-57个月）。12名发热儿童的平均最高体温（+/- SD）为39.3 ℃ +/- 0.9 ℃，所有儿童的平均总发热持续时间（+/- SD）为天（范围，1-5天）。2.6+/- 1.2 HCoV-NL 63感染发生在2002年春季和夏季，而HCoV-OC 43感染主要发生在2001年秋季和冬季。结论HCoV-NL 63病毒可分为两个进化谱系，且两个谱系的病毒在同一季节共流行。HCoV-NL 63是导致儿童住院的重要病原体，估计每10万人中有224人因HCoV-NL 63而住院。
Background. Human coronavirus NL63 (HCoV- NL63) is a recently discovered human coronavirus found to cause respiratory illness in children and adults that is distinct from the severe acute respiratory syndrome (SARS) coronavirus and human coronaviruses 229E (HCoV- 229E) and OC43 (HCoV- OC43).Methods. We investigated the role that HCoV- NL63, HCoV- OC43, and HCoV- 229E played in children hospitalized with fever and acute respiratory symptoms in Hong Kong during the period from August 2001 through August 2002.Results. Coronavirus infections were detected in 26 (4.4%) of 587 children studied; 15 (2.6%) were positive for HCoV- NL63, 9 (1.5%) were positive for HCoV- OC43, and 2 (0.3%) were positive for HCoV- 229E. In addition to causing upper respiratory disease, we found that HCoV- NL63 can present as croup, asthma exacerbation, febrile seizures, and high fever. The mean age (+/- standard deviation [SD]) of the infected children was 30.7 +/- 19.8 months ( range, 6-57 months). The mean maximum temperature (+/- SD) for the 12 children who were febrile was 39.3 degrees C +/- 0.9 degrees C, and the mean total duration of fever (+/- SD) for all children was days (range, 1-5 days). 2.6 +/- 1.2 HCoV- NL63 infections were noted in the spring and summer months of 2002, whereas HCoV- OC43 infection mainly occurred in the fall and winter months of 2001. HCoV- NL63 viruses appeared to cluster into 2 evolutionary lineages, and viruses from both lineages cocirculated in the same season.Conclusions. HCoV- NL63 is a significant pathogen that contributes to the hospitalization of children, and it was estimated to have caused 224 hospital admissions per 100,000 population aged