Chemerin analog regulates energy metabolism in sheep
Chemerin analog regulates energy metabolism in sheep
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DOI：
10.1111/j.1740-0929.2011.01002.x
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发表时间：
2012-01-01
影响因子：
2
通讯作者：
Roh, Sang-Gun
中科院分区：
文献类型：
--
作者：
Suzuki, Yutaka;Song, Sang-Houn;Roh, Sang-Gun
越来越多的数据表明，趋化蛋白与能量代谢之间存在一定的关系。本课题组之前描述了趋化蛋白及其自身受体在小鼠和牛身上的基因克隆、表达分析和调控机制。本研究的目的是利用一种生物稳定的趋化蛋白类似物，研究趋化蛋白对绵羊内分泌和能量代谢的生理影响。给绵羊静脉注射趋化蛋白类似物(100或500 mg/头)，分析血浆胰岛素及其代谢产物(葡萄糖、非酯化脂肪酸、甘油三酯、总胆固醇和高密度脂蛋白胆固醇)。趋化蛋白类似物显著提高了胰岛素水平，降低了血糖水平。NEFA水平在给药后20min略有下降，但在给药后60min~180min逐渐升高。此外，注射趋化蛋白类似物会立即增加甘油三酯和总胆固醇，但不会增加高密度脂蛋白的水平。这些结果提示趋化蛋白类似物在体内调节胰岛素的分泌与糖代谢和甘油三酯的释放有关。本研究为绵羊对趋化蛋白的内分泌和代谢变化提供了新的信息。
Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500 mu g/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20 min but then increased gradually from 60 to 180 min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.