Species-Specific Regulation of t-PA and PAI-1 Gene Expression in Human and Rat Astrocytes
Species-Specific Regulation of t-PA and PAI-1 Gene Expression in Human and Rat Astrocytes
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人类和大鼠星形胶质细胞中 t-PA 和 PAI-1 基因表达的物种特异性调控
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
C. Jern
中科院分区：
文献类型：
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作者：
A. Tjärnlund;K. Hultman;F. Blomstrand;M. Nilsson;R. Medcalf;C. Jern
近年来，丝氨酸蛋白酶组织型纤溶酶原激活物(t-PA)及其抑制物，包括纤溶酶原激活物抑制物-1(PAI-1)在脑内的作用和生理调节备受关注。然而，由于集中在这些问题上的研究很难在人类身上进行，到目前为止进行的大多数研究都利用了啮齿动物体内和/或体外模型。鉴于t-PA和PAI-1启动子存在物种特异性的结构差异，我们比较了这些基因在大鼠和人类来源的星形胶质细胞中的反应。我们发现，在不同生理和病理刺激处理后，基因诱导在数量和质量上存在显著的物种特异性差异。因此，我们的发现对于解释先前和未来与t-PA和PAI-1表达相关的结果具有重要意义。
In recent years, the role and physiological regulation of the serine protease tissue-type plasminogen activator (t-PA) and its inhibitors, including plasminogen activator inhibitor type-1 (PAI-1), in the brain have received much attention. However, as studies focusing these issues are difficult to perform in humans, a great majority of the studies conducted to date have utilized rodent in vivo and/or in vitro models. In view of the species-specific structural differences present in both the t-PA and the PAI-1 promoters, we have compared the response of these genes in astrocytes of rat and human origin. We reveal marked quantitative and qualitative species-specific differences in gene induction following treatment with various physiological and pathological stimuli. Thus, our findings are of importance for the interpretation of previous and future results related to t-PA and PAI-1 expression.
无 TATA 的大鼠组织型纤溶酶原激活剂基因的结构。
DOI：
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发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Feng,P;Ohlsson,M;Ny,T
通讯作者：
Ny,T